Cell-mediated immune mechanisms (CMI) were studied in 51 patients of pulmonary tuberculosis to evaluate the role of mycobacterium growth inhibitory factor in prognosis of the infection, before and after the administration of anti-tubercular drugs. Twenty five Mantoux negative individuals who were subsequently bacille Calmette-Guérin (BCG) vaccinated and 25 Mantoux positive, non-tuberculous cont...

A 55-year-old physician had a PPD made as part of a clinical evaluation. Laboratory tests were unremarkable and PPD, read in 48 hours, showed an area of induration of 18 mm and an erythema of 51 mm (Panel A). A 2 mm punch biopsy was done in the center of the induration 96 hours after the injection. Histopathology showed an intense perivascular cuffing with macrophages and lymphocytes and edema ...

After Mantoux testing with purified protein derivative (PPD) equivalent to 5 tuberculin units (TU), a 28 yr old man developed extensive erythema, induration and proximal lymphangitis. This is the only such case observed after Mantoux testing in approximately 500,000 subjects during 10 yrs in the Greek Army.

Two hundred paediatric cases of tuberculosis were studied over two years. The children usually presented with fever, cough, weight loss or failure to thrive and pallor. The diagnosis was based on history, clinical examination, chest and other relevant radiographs, Mantoux test, erythrocyte sedimentation rate (ESR) and where necessary cerebrospinal, pleural and ascitic fluid examinations and lym...

A patient with acquired chronic oral and vaginal candidiasis resistant to topical and parenteral therapy was found to have impaired cell mediated immunity to Candida antigen and loss of skin test response to tuberculin (Mantoux). Treatment with Candida-active transfer factor produced clinical remission lasting 1 year and restitution of in vitro and in vivo immune parameters. Relapse occurred wh...

Objective: To establish the role of Mantoux test in diagnosis tuberculosis children.Methods: The age group selected for this study was 5-18 years and period Aug 2018 to Feb 2020.Children attending our OPD with c/o fever & weight loss > 2 months were advised undergo along CBC ESR , CHEST X-RAY Sputum Examination AFB after taking detailed history including contact clinical examination .Res...