Saturable, high-affinity binding sites for 3,5,3'-triiodo-L-thyronine (T3) were identified in isolated nuclei and solubilized chromatin extracts of mammary glands, spontaneous mammary tumors, and liver from C3H/HeN mice. Receptor concentration in whole mammary gland nuclei (254 fmol/mg DNA) was only about one-half that of mouse liver nuclei (536 fmol/mg DNA), but in molecular weight (55,000) an...

We have previously demonstrated that the transcription factor nuclear factor (NF)1-C2 plays an important role in the mammary gland for the activation of the tumor suppressor gene p53. It also activates the milk genes carboxyl ester lipase and whey acidic protein, implying that NF1-C2 participates both in the establishment of a functional gland and in protection of the gland against tumorigenesi...

Carcinoma of an accessory mammary gland is an extremely rare tumor. A 61-year-old male patient presented with a hard mass measuring 85 mm × 51 mm in the left axilla. Incisional biopsy histopathologically showed an adenocarcinoma compatible with breast carcinoma originating in an accessory mammary gland. Systemic examinations revealed no evidence of malignant or occult primary lesion in the bila...

The Wnt-\ proto-oncogene is transcriptionally activated by mouse mammary tumor virus in mouse mammary tumor virus-induced tumors. Previous studies using transgenic mice showed that \\'nt-\ expression in mammary gland causes alveolar hyperplasias which resemble mam mary glands of pregnant mice. To understand the role of mammogenic hormones in the genesis of these hyperplasias, we examined the de...

The strain BALB/cNIV/Crgl was developed by infecting BALB/c/Crgl mice with mouse mammary tumor virus from C3Hf mice. A BALB/c normal mammary duct was transplanted into the gland-free fat pad of a hormone-stimulated female C3Hf X BALB/c F1 mouse. A hyperplastic alveolar nodule was found in the BALB/c ductal outgrowth and was transplanted into another hybrid gland-free fat pad. The resultant hype...

A 12-year-old Beagle dog weighing 7.7 kg was brought to the Brawijaya University Veterinary Teaching Hospital in a state of dehydration, lethargy, and jaundice. On 2nd day hospitalization, had mucopurulent discharge from vagina. From results complete blood count ultrasonography (USG), patient diagnosed with pyometra treated an ovariohysterectomy. After surgery dogs given cefotaxime 10 mg/kg bw,...

Maspin is a unique serine protease inhibitor of which the down-regulation is associated with the development of breast cancers. In vitro, recombinant maspin inhibits tumor cell migration and invasion. Overexpression of maspin in transgenic mice is protective against tumor progression. Additionally, maspin acts as an angiogenesis inhibitor in rat cornea model and in a xenograft tumor model. To a...

Saturable, high-affinity binding sites for 3,5,3'-triiodo-u-thyronine (T3) were identified in isolated nuclei and solubilized chromatin extracts of mammary glands, spontaneous mam mary tumors, and liver from C3H/HeN mice. Receptor concen tration in whole mammary gland nuclei (254 fmol/mg DMA) was only about one-half that of mouse liver nuclei (536 fmol/ mg DNA), but in molecular weight (55,000)...

Specific rabbit antisera and over 100 human sera were found to precipitate iodinated mouse mammary tumor virus (MTV). The specificity of these reactions was tested in competitive inhibition studies. Three classes of reaction could be distinguished. The Class 1 reaction was the most specific; it could be inhibited only by MTV and was observed exclusively with rabbit anti-MTV. The Class 2 reactio...

Mammary gland tumors are very rare in male dogs. In this study, four mammary gland tumors from 3 male dogs (2 intact, 1 neutered) were collected from local animal hospitals. The dogs included two purebred Shih Tzu (1 intact, 1 neutered) and one intact purebred Cocker Spaniel. The mean age of dogs with mammary gland tumors was 9 years (5-12 years). Two dogs had a solitary mass, whereas one dog h...