Morpholine-2,5-dione derivatives having substituents with benzyl-protected carboxylic acid, benzyloxycarbonyl-protected amine and p-methoxy-protected thiol groups, respectively, were prepared in 2958% yield by cyclization of the corresponding N-[(2RS)-bromopropionyl]L-amino acids. Polyesteramides with protected pendant functional groups were obtained by ringopening copolymerization of either &-...

Maltose-maleimide was synthesized as a potential affinity label for the facilitative hexose carrier with selectivity for exofacial sulphydryl groups. This reagent, although probably a mixture of isomers, did not significantly penetrate the plasma membrane of human erythrocytes at concentrations below 5 mM at 37 degrees C. When allowed to react to completion, it irreversibly inhibited the uptake...

Two basic and simple synthetic routes for mono- and bis-maleimide bearing 1,4,7-triazacyclononane-N,N',N''-triacetic acid (NOTA) chelators as new bifunctional chelators are described. The syntheses are characterized by their simplicity and short reaction times, as well as practical purification methods and acceptable to very good chemical yields. The usefulness of these two synthetic pathways i...

In situ EPR spectroscopy at cryogenic temperatures has been used to observe and identify paramagnetic species produced when titania is irradiated in the presence of reactants used in the photocatalytic alkylation of maleimide with t-butyl carboxylic acid or phenoxyacetic acid. It is shown that maleimide acts as an acceptor of conduction band electrons. Valence band holes oxidise t-butyl carboxy...

Mainand side-chain sequence-regulated vinyl copolymers with acid and base monomer units were prepared using atom transfer radical addition (ATRA) and alternating radical copolymerization. A series of maleimide-ended sequence-regulated “oligomonomers” were prepared by ATRA of t-butyl acrylate (tBA: Ap) (i.e., a protected acrylic acid (A)) or an amine-functionalized acrylate, (2-(dimethylamino)et...

Site-specific isopeptide linkages between the ε-amino group of a lysine residue in one protein and a carboxyl group in another are central to ubiquitin-mediated protein degradation and other cellular processes. These linkages are inaccessible with common recombinant DNA techniques. Here, we describe a method to link two proteins by an authentic isopeptide bond. The method unites three technique...

The teach pendant is a hand-held robot control terminal that provides a convenient means to move the robot, teach locations, and run robot programs. Nowadays, almost teaching pendant is connected with a robot controller using cable. The cable connection and the size of teaching pendant are not problems because a robot controller is separated with robot. However, a large size and wired teaching ...

This study was designed to demonstrate the cytoprotective effect of an antacid containing aluminium phosphate (Phosphalugel) against ethanol-induced gastric injury in the rat and to determine whether this cytoprotective effect is mediated by endogenous prostaglandins and sulfhydryls. We have quantitatively evaluated gastric mucosal lesions using macroscopic and histological techniques one hour ...