Background and Aims: Cola acuminata pod extract (CAPE) is used in Nigerian traditional medicine to treat low sperm count in males. Hence, this study aimed to investigate the effects of CAPE on the reproductive system of male albino rats. Materials and Methods: Preliminary acute toxicity testing, phytochemical screening, proximate analysis, and determination of vitamin E concentration were perf...

Background: Various investigations have established that carbon tetrachloride (CCl4), a clear, colourless, volatile, heavy and nonflammable liquid, causes generation of free radicals in many tissues such as testis. a wide range of side effects such as reproductive toxicity has been observed following the administration of this liquid in experimental animals. Numerous studies have shown that amo...

Tributyl phosphate (TBP) was tested for reproductive toxicity in rats. Thirty weanlings/sex (F0) were exposed to TBP in the diet ad libitum at 0, 200, 700, or 3000 ppm for 10 weeks and then randomly mated within groups for 3 weeks with continued exposure. F0 parents and 10 F1 weanlings/sex/dose were necropsied, and adult reproductive organs, urinary bladders (both sexes), kidneys (males), and l...

objective: cyclosporine (cs), a cyclic undecapeptide with potent immunosuppressive activity, causes several adverse effects including reproductive toxicity. this study aims to examine the ability of crataegus monogyna aqueous fruit extract as an antioxidant to protect against cs-induced reproductive toxicity. materials and methods: in this experimental study, 32 adult male wistar rats were divi...

Tertiary-butyl acetate (TBAC) was tested for subchronic toxicity in rats and mice and reproductive toxicity in rats at inhalation concentrations of 0, 100, 400 or 1600ppm. An oral maternal toxicity study was conducted in rats at dose levels of 0, 400, 800, 1000 and 1600mgkg(-1)d(-1). In the inhalation studies, hematology, clinical chemistry, urinalysis, gross pathology and the majority of body ...

Dwindling male fertility due to xenobiotics is of global concern. Accordingly, male reproductive toxicity assessment of xenobiotics through semen quality analysis in exposed males, and examining progeny production of their mates is critical. These assays, in part, are biased towards monogamy. Females soliciting multiple male partners (polyandry) is the norm in many species. Polyandry incites sp...

BACKGROUND Endosulfan has been used for over 50 years. Although most analogs have been discontinued, endosulfan has less environmental persistence. Nevertheless, pressure groups are lobbying for a worldwide ban. The reasons are: possible rodent male reproductive toxicity, other endocrine effects and cancer; human epidemiology, and exposure studies; residues appearing in remote areas of the worl...

Arsenic is a widespread metalloid in environment, whose exposure has been associated with a broad spectrum of toxic effects. However, a global view of arsenic-induced male reproductive toxicity is still lack, and the underlying mechanisms remain largely unclear. Our results revealed that arsenic exposure decreased testosterone level and reduced sperm quality in rats. By conducting an integrated...

Aspirin (Acetylsalicylic acid) is widely used in human and veterinary as anti-inflammatory, cardiovascular prophylaxis, anti-clotting agent and to decrease cancer risk. However, it is often misor over-consumed, including in population subgroups, such as elite athletes, to prevent pain and treat injuries. Many risks associated with its usage have been reported but there is a deficiency of inform...