The experimental carcinogenesis results in six compounds related to vinyl chloride are reported. Vinylidene chloride, given by inhalation, was carcinogenic in male CD-1 mice, male CD rats, Sprague-Dawley rats and male Swiss mice. Trichloroethylene, given by gavage and inhalation, was carcinogenic in the B6C3F1 mice. When given by gavage, perchloroethylene was carcinogenic in the B6C3F1 mice, an...

Although estrogen is implicated in the regulation of cell growth and differentiation in many organs, the exact mechanism for liver regeneration is not completely understood. We investigated the effect of estrogen on liver regeneration in male and female Wistar rats after 70% partial hepatectomy (PHx) and performed immunohistochemistry, western blotting and Southwestern histochemistry. 17β-estra...

Purpose: We aimed to investigate dragon fruit (Hylocereus polyrhizus) extract effectiveness by creating a nephropathy model with contrast media toxicity after dehydration and furosemide administration rats. 
 Methods: Total 36 male Sprague dawley rats were randomly allocated into 6 groups (n: 6). At the end of experiment kidney organs blood was taken for histopathologic biochemical analyze...

Testosterone and 5 alpha-dihydrotestosterone (DHT) concentrations in tissue and body fluid were determined in adult male rats to investigate the mode of androgen distribution. The highest concentration of androgen (testosterone + DHT) and the smallest ratio of DHT/testosterone were observed in the intratesticular tissue fluid. The androgen concentration in testicular vein blood was much higher ...

male infertility evaluation is important to recognize an origin and provide treatment if the etiology is correctable. the aim of the present study was to investigate the protective role of lavandula angustifolia in impaired spermatogenesis caused by cadmium chloride in male rats. 36 male wistar rats were allocated in 6 groups. cadmium chloride was injected for 3 consecutive days (0.5 mg/kg) in ...

Male animals with more conspicuous visual and acoustic signals increase their mating success, but also increase the risk of being attacked by eavesdropping predators. In rodents, males with richer sex pheromones often have higher attractiveness to females, but whether or not the males are also at higher predation risk is poorly known. Here, we used 2 laboratory inbred strains of the rat Rattus ...

The hydroxylating activities of liver microsomes for proges terone and testosterone were markedly decreased in male and female rats bearing Walker carcinosarcoma 256. The decreases in the hydroxylating activities were greater in the male rats than in the female rats. The content of cytochrome P-450 in liver microsomes was decreased in the tumor-bearing male and female rats. Moreover, the bindin...

The industrial solvent trichloroethylene (TCE) has been reported to increase the excretion of formic acid in the urine of male Fischer 344 (F-344) rats following large oral doses. We have examined the dose-response relationship for formic aciduria in male and female Fischer 344 rats, the effect of some known metabolites of TCE and examined the response in male Wistar rats to help understand its...

obesity influences semen quality by hormonal imbalance. therefore, the aim of this study was to examine the effect of moderate and intensive aerobic training on obese male rats' reproductive function. 30 obese male rats were assigned to moderate training (n=10), intensive training (n=10) and control (n=10) groups. a matched control group of normal weight rats (n=10) were also recruited for...

Objective: To determine the regenerating effect of hyaluronic acid on circumferential bone defects in albino Wistar rats. Material and Methods: An experimental type study was designed carried out with 15 male rats, 4 months old weighing between 250 350 grams. Two 3mm diameter 0.8mm deep were created calvaria parietal (on both sides midline). One defect filled a demineralized matrix (control gro...