نتایج جستجو برای: malarial parasites

تعداد نتایج: 42725  

Journal: :Acta medica Okayama 2000
K Kamei H Matsuoka S I Furuhata R I Fujisaki T Kawakami S Mogi H Yoshihara N Aoki A Ishii T Shibuya

To find a new anti-malarial medicine derived from natural resources, we examined the leaves of 13 common Japanese plants in vitro. Among them, a leaf-extract of Hydrangea macrophylla, a common Japanese flower, inhibited the parasitic growth of Plasmodium falciparum. The IC50 of Hydrangea macrophylla leaf extract to Plasmodium falciparum was 0.18 microg/ml. The IC50 to NIH 3T3-3 cells, from a no...

Journal: :The Journal of Experimental Medicine 2003
Mary Rowley-Lawson

1. What appear to be certain definite stages in the migration of the malarial parasite from red corpuscle to red corpuscle may be demonstrated by thorough and persistent observations,-not minutes spent on each specimen, but many hours. 2. The migration of the malarial parasite from red corpuscle to red corpuscle gives a reasonable explanation of the loss of red corpuscles which cannot be accoun...

2008
H.J.W. Sturrock D. M. Tompkins

There is concern that avian malaria maybe partly responsible for fluctuations in yellow-eyed penguin (Megadyptes antipodes) populations in New Zealand. Recent findings, however, have provided no evidence of avian malaria parasites infecting yellow-eyed penguins on the Otago Peninsula, raising questions as to whether this area is currently free of such parasites. To test this possibility we coll...

Journal: :Revista do Instituto de Medicina Tropical de Sao Paulo 1986
E L Franco

This literature review discusses the most frequently used serodiagnostic methods for the determination of the humoral immune response to malarial parasites. The importance of malaria as a global public health problem is stressed in the light of the new discoveries leading to the future development of an anti-malarial vaccine suitable for use in humans. Serological techniques are expected to pla...

Journal: :Chemical Society reviews 2010
Devdutt Chaturvedi Abhishek Goswami Partha Pratim Saikia Nabin C Barua Paruchuri G Rao

In this tutorial review, an effort towards presentation of a comprehensive account of the recent developments on various kinds of artemisinin derivatives including artemisinin dimers, trimers and tetramers has been made and their efficacy towards malaria parasites and different cancer cells lines was compared with that of artemisinins, and various other anti-malarial and anti-cancer drugs. It i...

2011
Hong Cai Rui Kuang Jianying Gu Yufeng Wang

Malaria continues to be one of the most devastating global health problems due to the high morbidity and mortality it causes in endemic regions. The search for new antimalarial targets is of high priority because of the increasing prevalence of drug resistance in malaria parasites. Malarial proteases constitute a class of promising therapeutic targets as they play important roles in the parasit...

2014
Yuseob Kim Ananias A. Escalante Kristan A. Schneider

To develop public-health policies that extend the lifespan of affordable anti-malarial drugs as effective treatment options, it is necessary to understand the evolutionary processes leading to the origin and spread of mutations conferring drug resistance in malarial parasites. We built a population-genetic model for the emergence of resistance under combination drug therapy. Reproductive cycles...

2009
Mohammad Iqbal Yasinzai Juma Khan Kakarsulemankhel

This paper reports the prevalence of malarial parasites in the human population of District Ziarat and Sanjavi. Out of a total of 3765 blood samples 26.8% were found positive for malarial parasite. The incidence of Plasmodium falciparum was 69.5% and that of P. vivax was 30.2%. The incidence was higher (75.9%) in males. Age wise, the prevalence of the disease was 22.2% in Ziarat and 35.2% in Sa...

2016
Sayli S. Modak Cheryl A. Barber Eran Geva William R. Abrams Daniel Malamud Yhombi Serge Yvon Ongagna

Malaria remains one of the most prevalent infectious diseases and results in significant mortality. Isothermal amplification (loop-mediated isothermal amplification) is used to detect malarial DNA at levels of ~1 parasite/µL blood in ≤30 minutes without the isolation of parasite nucleic acid from subject's blood or saliva. The technique targets the mitochondrial cytochrome oxidase subunit 1 gen...

Journal: :Journal of the College of Physicians and Surgeons--Pakistan : JCPSP 2013
Muhammad Usman Shah Murtaza Ali Sundhu Muhammad Zahid Hussain

Pancytopenia is a condition with decreased numbers of all cell lines. Aplastic anemia is a common cause although malarial infection causing lysis of RBCs may also partly mimic this condition. The infection may also damage the patient's bone marrow resulting in pancytopenia as well. We present the case of a post-partum female patient who reported with fever, body aches and shortness of breath on...

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