[email protected] Abstract Systemic Anti-malarial Drugs (SADs) are commonly used to treat autoimmune diseases and are generally considered a benign medication. SAD-induced psoriasis has been reported in the literature, but evidence is conflicting regarding the strength of the association of SAD and psoriasis exacerbations. We present a case of hydroxychloroquine-induced psoriasis exacerbat...

1. Two important methods for the study of malarial pigment are described. (a) A method for obtaining a solution of malarial pigment from fixed tissues without the removal of a trace of hemoglobin from the red blood corpuscles. (b) A method for obtaining an iron reaction in malarial pigment. 2. By comparing the bleach reactions and solubility of melanins and malarial pigment, the dissimilarity o...

BACKGROUND This study was conducted in a private clinic to report frequency, presentation and management of malaria in children presenting with fever. METHODS 160 Children of age varying from 42 days to 15 years were included in this study, during a period of 1999-2004. RESULTS AND CONCLUSIONS Malaria was confirmed in 154 cases, including 114 male and 46 female children. In 6 cases malarial...

Set in an unspecified time in the future, this medical thriller takes the readers through a wondrous journey of time. The narrative is suffused with science, myth, nihilism, philosophy and superstition. The book is based on the life of the Nobel Prize winning scientist, Sir Ronald Ross, who did a breakthrough research on malaria in 1989. It is an attempt to rewrite the story of Ronald Ross’s di...

Malaria is endemic in most developing countries, with nearly 500 million cases estimated to occur each year. The need to design a new generation of antimalarial drugs that can combat the most drug-resistant forms of the malarial parasite is well recognized. In this study, we wanted to develop inhibitors of key proteins that form the invasion machinery of the malarial parasite. A critical featur...

New anti-malarial drugs are needed to meet the challenge of Background: artemisinin resistance and to achieve malaria elimination and eradication. The new anti-malarial compounds are expected to have many desirable properties, such as activity against multiple stages of , low host cytotoxicity, Plasmodium and low propensity for resistance development, but whether and how these properties might ...

AIM OF STUDY The ethnobotanical study surveyed the different types of medicinal plants used for the treatment of malaria in the south-western region of Nigeria. MATERIALS AND METHODS Information was collected by interviewing indigenous people, using a semi-structured questionnaire. Collected plant samples were identified and authenticated in Forestry Research Institute of Nigeria, Ibadan, Nig...

BACKGROUND AND OBJECTIVE Dihydroartemisinin-piperaquine (DhP) is a very cost effective anti-malarial drug. The aim of this study was to predict the budget impact of using DhP as a first- or second-line drug to treat uncomplicated malaria in children in Tanzania. METHODS A dynamic Markov decision model was developed based on clinical and epidemiological data to estimate annual cases of malaria...