Mutations within the class I major histocompatibility complex (MHC) molecule that affect a peptide binding can result in strong allogeneic responses. It is believed this reflects, in part, binding of a different set of endogenous peptides by each MHC molecule. We have examined the representation of allopeptides recognized by Kb-specific cytotoxic T lymphocytes (CTL) clones among targets that ex...

Leishmania major was proposed to either utilize haem from its host or partially synthesize the tetrapyrrole from host provided precursors. However, only indirect evidence was available for this partial late haem biosynthetic pathway. Here, we demonstrate that the LMJF_06_1280 gene of L. major encodes a HemG-type PPO (protoporphyrinogen IX oxidase) catalysing the oxidation of protoporphyrinogen ...

OBJECTIVES Bipolar type II (BP II) disorder is thought to be distinct from BP I disorder on genetic and biological grounds, and it is not merely a milder form of the illness. It affects 1.5-2.5% of the US adult population, and is characterized by highly recurrent depressive episodes with a substantial morbidity from alcoholism and non-affective psychopathology, and a higher suicide rate than ei...

We search for ongoing major dry-mergers in a well selected sample of local Brightest Cluster Galaxies (BCGs) from the C4 cluster catalogue. 18 out of 515 early-type BCGs with redshift between 0.03 and 0.12 are found to be in major dry-mergers, which are selected as pairs (or triples) with r-band magnitude difference δmr < 1.5 and projected separation rp < 30 kpc, and showing signatures of inter...

criterion for assessment of observed variability. Given an inherent variability of +20% for each method under comparison, the combined variability (i.e. limits of agreement) should not exceed +30% of the mean SVV. Applying these strict criteria to the data, agreement of methods studied by the authors was unacceptable. Secondly, the authors compared SV derived from different methods at specified...

coronary artery disease (cad) is the most important cause of mortality and morbidity in the world. the knowledge of major risk factos can be useful in prevention of cad. there is no known major risk factof in many patients with myocardial infarction (mi). the dermatoglyphic pattern in patients with myocardial infarction is an interesting matter and little information is available about this rel...

Pneumocystis carinii are coated by abundant surface proteins, named MSGs for major surface glycoproteins, that undergo antigenic variation. There are many MSG genes on the chromosomes but the MSG expression site is restricted to a unique site called type-I UCS, and silent MSG genes can be translocated to the expression site by DNA recombination. We have reported previously the existence of alte...

The aim of this investigation was to identify the domains of type IV collagen participating in cell binding and the cell surface receptor involved. A major cell binding site was found in the trimeric cyanogen bromide-derived fragment CB3, located 100 nm away from the NH: terminus of the molecule, in which the triple-helical conformation is stabilized by interchain disulfide bridges. Cell attach...