systems were comprised of subroutines and procedures formatted in source code. Typical maintenance on such systems would include impact analysis, which determines if and how different system parts interact, and regression testing, which uses test code inputs from earlier versions to ensure system integrity after maintenance. For such systems, impact analysis was often sufficient to determine wh...

We examine the problem of how to ensure behavioral consistency of an object-oriented system after its schema has been updated. The problem is viewed from the perspective of both the strongly typed and the untyped language model. Solutions are compared in both models using C++ and CLOS as examples.

Poor quality software and projects that fail to deliver are a toofrequent occurrence. There is thus a clear need for greater professionalism throughout the sector and this must be supported by appropriate Continuous Professional Development (CPD). Details are presented of foundation work, undertaken since 2000, relevant to the on-going professional development of IT practitioners. Information i...

DWT is a tool for the maintenance of data warehouse structures based on the temporal data warehouse model COMET. Data warehouse systems do not provide support for maintaining changes in dimension data. DWT allows keeping track of modifications made in the dimension-structure of multidimensional cubes stored in an OLAP (On-Line Analytical Processing) system. We present the overall structure of t...

The Short stop (Shot/Kakapo) spectraplakin is a giant cytoskeletal protein, which exists in multiple isoforms with characteristics of both spectrin and plakin superfamilies. Previously characterized Shot isoforms are similar to spectrin and dystrophin, with an actin-binding domain followed by spectrin repeats. We describe a new large exon within the shot locus, which encodes a series of plakin ...

A partition of a set is a collection of subsets that are pair-wise mutually exclusive and whose union includes every member of the set. In many graph algorithms it’s useful to have a data structure for maintaining a partition on the vertices of the graph that allows us to quickly determine if two vertices are in the same subset, and to quickly combine two subsets. More precisely, the partition ...

Introduction Genomes have always been vulnerable to damage from intraand extracellular sources such as oxidative species generated by cell metabolism, spontaneous base loss or modification, radiation and chemicals (Friedberg et al, 2005a). As a result, mechanisms to cope with DNA damage developed early in evolution and have been conserved. Organisms need some genome stability, but must allow mu...