Proton MR spectroscopy (MRS) studies have found both decreased N-acetylaspartate (NAA) and increased myo-inositol in the occipital, temporal, parietal, and frontal regions of patients with AD, even at the early stages of the disease. This diffuse NAA decline is independent of regional atrophy and probably reflects a decrease in neurocellular viability. Reports of such metabolite changes are now...

(Nuclear) Magnetic Resonance ((N)MR) is a non-invasive technique that has been used to acquire spatially resolved images of living organisms. Another application of clinical MR is MR Spectroscopy (MRS) in which chemical information can be extracted from a well-defined region (e.g. a voxel) in for example the human brain [de Graaf, 1998]. Brain tumors [Nelson, 1999], multiple sclerosis, epilepsy...

Nuclear Magnetic Resonance (NMR) is a spectroscopic technique widely used by organic chemists. NMR provides details about the location, number and environment of specific types of atoms within a sample. The proper interpretation of this information allows detailed chemical structures to be discerned. The same basic instrumentation used in this week’s experiment is used in physician offices when...

Background Skeletal muscle metabolic abnormalities have been described in patients with heart failure that are independent of total limb perfusion, histochemical changes, and muscle mass. However, these skeletal muscle metabolic abnormalities may result from tissue hypoxia caused by maldistribution of flow. Myoglobin is an 02 binding protein that can indirectly assess tissue hypoxia. Methods an...

Magnetic resonance (MR) spectroscopy is an analytical method used in chemistry that enables the identification and quantification of metabolites in samples. It differs from conventionalMR imaging in that spectra provide physiologic and chemical information instead of anatomy. MR spectroscopy and MR imaging have their origin in nuclear magnetic resonance (NMR). NMR was first described in 1946 si...

In vivo proton magnetic resonance spectroscopy (1HMRS) can substantially improve the non-invasive categorization of human brain tumors, especially for gliomas. It provides greater information concerning tumor activity and characterization of the tumor tissue than is possible with MRI techniques alone. Moreover, 1HMRS may ultimately prove to be a highly beneficial modality in the post-irradiatio...

Background. Nuclearmagneticresonanceisa non-destructive andnon-invasive t chnology that is highly suited for research in psychiatry. It is establishing itself as a versatile means of studying brain morphology, chemistry and function and is finding a place in the diagnosis of disease, monitoring of treatment and the study of basic brain processes. Method. A literature review was undertaken. Resu...

A new approach for accurate quantitative determination by fluorine nuclear magnetic resonance ( 19 F NMR) spectroscopy is presented and discussed. 19 F NMR spectroscopy has similar properties to 1 H NMR spectroscopy except for the wide chemical shift dispersion, which is the main difference between the two techniques. The off-resonance effect, which is caused by the chemical shift difference be...

This paper presents a methodology allowing to estimate the parameters of two-dimensional damped/undamped sinusoids from high complexity noisy signals, which is the case in 2-D nuclear magnetic resonance spectroscopy. The proposed approach performs an adaptive subband decomposition combined with a classical frequency estimator based on the Prony model. At each node resulting from the decompositi...