The use of magnetic iron oxide nanoparticles in biomedicine has evolved intensely in the recent years due to the multiple applications of these nanomaterials, mainly in domains like cancer. The aim of the present study was: (i) to develop biocompatible colloidal suspensions based on magnetic iron oxide nanoparticles as future theranostic tools for skin pathology and (ii) to test their effects i...

In this work, we report synthesis of surface modified superparamagnetic iron oxide nanoparticles (SPION) by co-precipitation method using FeSO4.7H2O and Fe2(SO4)3.5H2O as precursors and trisodium citrate dihydrate as surfactant. Surface modification of the as prepared samples was performed in pot by sol-gel precipitation method u...

Superparamagnetic iron oxide nanoparticles produce changes in the surrounding microscopic magnetic field. A method for generating contrast based on the application of an adiabatic preparation pulse and the failure of the adiabatic condition surrounding the nanoparticles is introduced in this article. Images were obtained in the presence and absence of an adiabatic preparation pulse and the diff...

  Background: Ultrasmallsuperparamagnetic iron oxide (USPIO) nanoparticles are used as blood pool contrast agent for magnetic resonance angiography and perfusion imaging. Our aim in this study was to investigate the effect of the two coating types of iron oxide nanoparticles on the relationship between nanoparticles concentration and signal intensity (SI) in T1-weighted MR images.   Methods : D...

Although iron oxide magnetic nanoparticles (MNP) have been proposed for numerous biomedical applications, little is known about their biotransformation and long-term toxicity in the body. Dimercaptosuccinic acid (DMSA)-coated magnetic nanoparticles have been proven efficient for in vivo drug delivery, but these results must nonetheless be sustained by comprehensive studies of long-term distribu...

Magnetic inducing hyperthermia (MIH) is gaining great popularity due to its good targeted therapy and less side effects. Magnetic agents play a crucial role in this technique. As novel candidates, recently, carbon nanotubes/iron oxide nanoparticles composites have demonstrated great potential in MIH by combining the unique characteristics of carbon nanotubes with the excellent magnetic properti...

Iron oxide exhibits fascinating physical properties especially in the nanometer range, not only from the standpoint of basic science, but also for a variety of engineering, particularly biomedical applications. For instance, Fe3O4 behaves as superparamagnetic as the particle size is reduced to a few nanometers in the single-domain region depending on the type of the material. The superparamagne...

Iron oxide exhibits fascinating physical properties especially in the nanometer range, not only from the standpoint of basic science, but also for a variety of engineering, particularly biomedical applications. For instance, Fe3O4 behaves as superparamagnetic as the particle size is reduced to a few nanometers in the single-domain region depending on the type of the material. The superparamagne...

In this work, we report synthesis of surface modified superparamagnetic iron oxide nanoparticles (SPION) by co-precipitation method using FeSO4.7H2O and Fe2(SO4)3.5H2O as precursors and trisodium citrate dihydrate as surfactant. Surface modification of the as prepared samples was performed in pot by sol-gel precipitation method u...

In this paper, we demonstrate the tunable T1 and T2 contrast abilities of engineered iron oxide nanoparticles with high performance for liver contrast-enhanced magnetic resonance imaging (MRI) in mice. To enhance the diagnostic accuracy of MRI, large numbers of contrast agents with T1 or T2 contrast ability have been widely explored. The comprehensive investigation of high-performance MRI contr...