BACKGROUND Atrial fibrillation (AF) is the most common cardiac arrhythmia. Magnesium has been reported to be effective in reducing the incidence or prophylaxis of AF. Magnesium is also an essential constituent of many enzyme systems and plays a physiological role in coagulation regulation. The aim of the present study was to examine the effects of magnesium, whether magnesium infusion might dec...

In this study, fertilized mirror carp eggs were allowed to develop in fresh water with various magnesium concentrations (0.05, 0.2 and 2 mg l). The percentage of dead (eggs+prelarvae) and deformed prelarvae increased sharply to 94% at an ambient magnesium concentration of 0.05 mg l compared with 22 and 10% at ambient magnesium concentrations of 0.2 mg l and 2.0 mg l, respectively. Mirror carp r...

Despite its success as a potent antineoplastic agent, ∼25% of patients receiving cisplatin experience acute kidney injury (AKI) and must discontinue therapy. Impaired magnesium homeostasis has been linked to cisplatin-mediated AKI, and because magnesium deficiency is widespread, we examined the effect of magnesium deficiency and replacement on cisplatin-induced AKI in physiologically relevant o...

Infusion of magnesium salts into the body cavity of freshwater-adapted rainbow trout led to elevated plasma magnesium concentrations and to stimulation of renal tubular secretion of magnesium. The majority of the infused load was excreted renally, no net branchial excretion being detected. Magnesium sulphate infusion led to increased tubular secretion of sulphate. Magnesium chloride infusion le...

Magnesium deficiency is frequently associated with hypokalemia. Concomitant magnesium deficiency aggravates hypokalemia and renders it refractory to treatment by potassium. Herein is reviewed literature suggesting that magnesium deficiency exacerbates potassium wasting by increasing distal potassium secretion. A decrease in intracellular magnesium, caused by magnesium deficiency, releases the m...

Carp eggs, fertilized in vitro, were allowed to develop in fresh water with magnesium concentrations varying from 0.001 to 0.100 mmol l-1. Magnesium concentrations below 0.010 mmol l-1 seriously impeded carp embryonic development: the incidence of deformed larvae and mortality increased steeply to 100% at water magnesium concentrations of 0.001 mmol l-1. Thus, early life stages of carp require ...

INTRODUCTION Magnesium is an essential micronutrient for human body, and its deficiency has been associated with risk of non-communicable diseases. OBJECTIVE Assessment of magnesium status, and evaluation of the frequency of magnesium deficiency in a group of healthy adults. METHODS Plasma and erythrocyte magnesium levels, and magnesium intake were determined in 115 students (55 women and 6...

The use of high-dose magnesium infusions in critically ill and surgical patients is increasing. This practice is associated with considerable risk of toxicity, as no reliable criteria are currently available to detect significant intracellular magnesium depletion. We have evaluated, before and after surgery, 33 elderly patients with hip fracture, by 24-h Holter ECG monitoring, Doppler echocardi...

The kidney has a vital role in magnesium homeostasis and, although the renal handling of magnesium is highly adaptable, this ability deteriorates when renal function declines significantly. In moderate chronic kidney disease (CKD), increases in the fractional excretion of magnesium largely compensate for the loss of glomerular filtration rate to maintain normal serum magnesium levels. However, ...

The antidepressant- and anxiolytic-like effects of magnesium, an N-methyl-d-aspartate (NMDA) glutamate receptor inhibitor, were studied in mice using the forced swim test and elevated plus-maze test, respectively. The doses of 20 and 30 mg Mg/kg, reduced immobility time in the forced swim test exerting antidepressant-like activity. In the elevated plus-maze test, magnesium at the same doses pro...