BACKGROUND Macrosomia has been defined in various ways by obstetricians and researchers. The purpose of the present study was to search for a definition of macrosomia through an outcome-based approach. METHODS In a study of 30,831,694 singleton term live births and 38,053 stillbirths in the U.S. Linked Birth-Infant Death Cohort datasets (1995-2004), we compared the occurrence of stillbirth, n...

Background: Weight in infancy correlates with risk of type 2 diabetes, hypertension, and obesity in adulthood. Clinical observations have been confounded by obesity-prone genotypes and obesity-linked lifestyles. Objectives: To define the effects of isolated neonatal macrosomia in isogenic animals, we compared macrosomic and control C57Bl6 mice co-fostered by healthy dams receiving standard labo...

www.thelancet.com Published online April 9, 2015 http://dx.doi.org/10.1016/S0140-6736(14)62302-3 1 Fetal macrosomia (usually defi ned as an estimated fetal weight or birthweight >4000 g or ≥4500 g) is associated with various perinatal complications. Irrespective of which weight threshold is used, macrosomic fetuses have higher rates of shoulder dystocia and subsequent birth trauma than do non-m...

BACKGROUND Despite the interest in the impact of overweight and obesity on public health, little is known about the social and economic impact of being born large for gestational age or macrosomic. Both conditions are related to maternal obesity and/or gestational diabetes mellitus (GDM) and associated with increased morbidity for mother and child in the perinatal period. Poorly controlled diab...

BACKGROUND Cree births in Quebec are characterized by the highest reported prevalence of macrosomia (~35%) in the world. It is unclear whether Cree births are at greater elevated risk of perinatal and infant mortality than other First Nations relative to non-Aboriginal births in Quebec, and if macrosomia may be related. METHODS This was a population-based retrospective birth cohort study usin...

Newborn weight exceeding 4000 g or 4500 is considered as macrosomia, incidence of which varies from 6 to 10% all deliveries. Maternal diabetes, obesity, age >35 years, male baby, history previous multiparity are few risk factors. It associated with several maternal and neonatal complications presents an obstetric challenge there no consensus regarding the most appropriate route delivery for ...

OBJECTIVE Macrosomia is one of the most common complications in gestational diabetes mellitus. Insulin-like growth factor 2 and H19 are two of the imprinted candidate genes that are involved in fetal growth and development. Change in methylation at differentially methylated region of the insulin-like growth factor 2 and H19 has been proved to be an early event related to the programming of meta...