The in vitro antimicrobial potency of 10-aza-9-deoxo-11-deoxyerythromycin A, the first member of a new class of macrolide antibiotic, was determined. Several other members of this family of azalide were prepared and similarly screened in order to begin to define the antibiotic potential of the class. The results indicate that the SAR for this structural type parallels that of other macrolides a...

Reidispongiolide A is a representative member of the sphinxolide/reidispongiolide group of cytotoxic 26-membered macrolides of marine origin. By interacting with actin in the cell cytoskeleton, the reidispongiolides and sphinxolides are potent microfilament destabilizing agents that represent a promising mechanism of action for developing novel anticancer drugs. An aldol-based synthesis of a li...

New 16-membered macrolide antibiotics 6108 Al (1), B (2), C (3) and D (4) were isolated from the culture filtrate of a Micromonosporafastidiosus sp. 1 }. From the physico-chemical, spectroscopic data and chemical degradation studies, these compoundswere shownto be analogs of rosaramicin (5)2), whose structures were different from 5 at the C-18 position. In this paper, we describe the structure ...

screened for high-frequency transfer of OTC resistance. Although such strains were found at quite a high frequency (about 1 in IOOO), it was subsequently discovered that a second plasmid SRP2 had actually been primed. This possessed much weaker sex-factor activity than SRPl . Neither plasmid has proved amenable to physical isolation or analysis, and with the advent of recombinant DNA techniques...

With the increasing resistance of group A streptococci (GAS) to macrolides in some countries including Korea, throat cultures were taken from healthy elementary school children to isolate GAS in 2004. Antibiotic susceptibility, macrolide-resistant phenotypes and genotypes as well as emm genotyping were studied and compared with previous data in 2002. In the present study, resistance rates to er...