Background: Familial Mediterranean fever (FMF) is the most common hereditary auto-inflammatory disease, which more in groups basin, characterized by recurrent attacks of febrile peritonitis, pleuritis and arthritis. Objectives: The aim this study to investigate gender differences clinical demographic features patients with familial (FMF). Methods: Patients FMF diagnosed according Tel-Hashomer c...

Introduction Mutations M680I, M694V and V726A of Pyrin the product of MEFV gene are localized at the domain B30.2 (PB30.2D) and responsible for manifestation of the most widespread and severe forms of FMF. From the other hand, it is well known that malfunction of the pyrin-caspase-1complex is the main reason for inflammation during FMF. Therefore, we suggest that comparative investigation of no...

Objective(s):Familial Mediterranean fever (FMF), an inherited autosomal recessive disorder, is frequently present among individuals of Mediterranean origin. Differences in the clinical manifestations of FMF between different ethnic groups have been documented. The aim of the present study was to determine the most common characteristics of FMF and the relationship between clinical findings and ...

. Conca W, Ghatasheh G, Al-Salam S, Neidl Van Gorkom K. The medical odyssey of a boy with arthritis of familial Mediterranean fever. Int J Rheum Dis. 2012;15:37--9. . Lidar M, Kedem R, Mor A, Levartovsky D, Langevitz P, Livneh A. Arthritis as the sole episodic manifestation of familial Mediterranean fever. J Rheumatol. 2005;32:859--62. . Majeed HA, Rawashdeh M. The clinical patterns of arthriti...

BACKGROUND Among hereditary fevers characterized by recurrent attacks of fever and organ localized inflammation, familial Mediterranean fever (FMF), and tumour necrosis factor receptor superfamily 1A (TNFRSF1A) receptor associated periodic syndrome (TRAPS) are diseases with identified genes that can be associated with renal amyloidosis of the AA type. In this study we have characterized FMF and...

BACKGROUND Familial Mediterranean Fever (FMF) is an autosomal inherited disorder affecting certain races including Arabs. Diagnosis depends mainly on clinical basis, but mild forms may remain undiagnosed. OBJECTIVES This study aims at an accurate diagnosis of FMF in Egyptian children by detection of genetic mutations in addition to clinical assessment. SUBJECTS AND METHODS Subjects included...

OBJECTIVES Familial mediterranean fever (FMF) is an autosomal recessive disease characterized by recurrent and self-limiting fever, peritonitis, arthritis, synovitis, pleuritis, carditis, and erysipelas-like lesions. The aim of this study was to investigate the frequency of the MEFV gene mutation in patients who admitted to hospital with preliminary diagnosis FMF and who had undergone a prior a...