BACKGROUND Titin is a gigantic protein located in the thick filament of vertebrate muscles. The putative functions of titin range from interactions with myosin and other muscle proteins to a role in muscle recoil. Analysis of its complete sequence has shown that titin is a multi-domain protein containing several copies of modules of 100 amino acids each. These are thought to belong to the fibro...

To assess the possible existence of unbalanced chromosomal abnormalities and delineate the characterization of copy number alterations (CNAs) of acute myeloid leukemia-M5 (AML-M5), R-banding karyotype, oligonucelotide array CGH and FISH were performed in 24 patients with AML-M5. A total of 117 CNAs with size ranging from 0.004 to 146.263 Mb was recognized in 12 of 24 cases, involving all chromo...

The group A streptococcal M protein is an important virulence determinant eliciting protective and autoimmune responses against the streptococcus and cardiac myosin, respectively. In this report, the major human cardiac myosin-cross-reactive T-cell epitopes of M5 protein are identified and localized to myosin-like repeats within the M5 molecule. BALB/c mice were immunized with human cardiac myo...

Mature dolichol-linked oligosaccharides (mDLOs) needed for eukaryotic protein N-glycosylation are synthesized by a multistep pathway in which the biosynthetic lipid intermediate Man5GlcNAc2-PP-dolichol (M5-DLO) flips from the cytoplasmic to the luminal face of the endoplasmic reticulum. The endoplasmic reticulum membrane protein Rft1 is intimately involved in mDLO biosynthesis. Yeast genetic an...

Wind speed (WS) is an important factor in wind power generation. Because of this, drastic changes the WS make it challenging to analyze accurately. Therefore, this study proposed a novel framework based on stacking ensemble machine learning (SEML) method. The application for modeling was developed at sixteen stations Iran. SEML method consists two levels. In particular, eleven (ML) algorithms s...

Pep M5, the pepsin-derived N-terminal half of the group A streptococcal type 5 M protein exhibits immunologic crossreaction with type 6 M protein, localizing some of the M6-crossreactive epitope(s) within this segment of the M5 protein. Based on the amino acid sequence of the Pep M5 protein, two structurally distinct domains have been recognized within its coiled-coil structure. We have now fou...

Three studies (Ns = 183, 75, 123) examined the utility of the M5 Questionnaire (McCord, 2002), based on the five-factor model of personality (FFM), in assessing psychopathic personality traits in three separate undergraduate college student samples from the same public university in the Southeastern United States. Participants completed the M5 Questionnaire, a 336-item FFM instrument derived fr...

advanced data mining techniques can be used in universities classification, discovering specific patterns in the determination of successful students, design of a plan or a teaching method and finding critical points of financial management. in this article, we proposed a method to predict the rate of student enrollment in coming years. the data for this research were from data sets of voluntee...

We report on 5 years of pulsar observations of the globular cluster NGC5904 (M5). A timing model has been obtained for the two known pulsars, and a deep search for additional faint isolated pulsars has lowered the detection ux limit vefold without further detection. We discuss the details and implications of the phase coherent timing models for PSR B1516+02A and PSR B1516+02B. Of particular int...