T-cell molecular mimicry between streptococcal and heart proteins has been proposed as the triggering factor leading to autoimmunity in rheumatic heart disease (RHD). We searched for immunodominant T-cell M5 epitopes among RHD patients with defined clinical outcomes and compared the T-cell reactivities of peripheral blood and intralesional T cells from patients with severe RHD. The role of HLA ...

Deep Hubble Space Telescope (HST) photometry has recently been presented for the outer-halo globular clusters Palomar 4 and Eridanus. The new high-precision color-magnitude diagrams obtained for these globulars have allowed a measurement of their ages relative to M5 (NGC 5904), which is a wellobserved, much closer cluster. Assuming that the globular clusters share the same chemical composition,...

We study the worldvolume supersymmetric gauge theory of Mbranes probing backgrounds corresponding to wrapped M5-branes. In the case of M5-branes wrapping a 2-cycle in C2, we use M2-brane probes to compute the BPS spectra of the corresponding N = 2 gauge theory as well as M5-brane probes to calculate field theory parameters such as the gauge coupling, theta angle and complex scalar moduli space ...

In the Berkooz-Douglas matrix model of M theory in the presence of longitudinal M5-brane, we investigate the effective dynamics of the system by considering the longitudinal M5-brane as the background and the spherical M5-brane related with the other space dimensions as the probe brane. Due to there exists the background field strength provided by the source of the longitudinal M5-brane, an ope...

In this study a synthetic analog of the calmodulin-binding domain of myosin light chain kinase, a 17-amino-acid peptide (M5) was used to examine the possible role of calmodulin in melanotropin receptor function. Binding of beta-melanocyte-stimulating hormone to its membrane receptor and subsequent stimulation of adenylate cyclase (AC) were found to be specifically inhibited by M5 in a dose-depe...

We have used a set of overlapping chemically synthesized peptides representing the amino terminus of type 5 streptococcal M protein to localize protective, as opposed to nonprotective and tissue-crossreactive epitopes that might be appropriate for vaccine formulations. Rabbit antisera raised against SM5(1-35) reacted in high titer with pep M5 by ELISA and opsonized type 5 streptococci. None of ...

BACKGROUND In myeloid blasts, the expression and release of the multifunctional chemokine IL-8 could be expected to be differentiation-associated. METHODS We investigated the profile of interleukin-8 (IL-8) expression and release by leukemic cells obtained at diagnosis from 42 untreated adult patients with acute myeloid leukemia of various FAB subtypes (2 M0, 7 M1, 6 M2, 6 M3, 10 M4 and 11 M5...

The biotransformation of taxol by human liver was investigated in vitro with microsomes isolated from adult and developing human tissues. In vitro, no metabolism was detected with kidney microsomes, whereas two metabolites were generated by liver microsomes. The most prominent metabolite, termed M5, corresponded to an hydroxylation at the C6 position on the taxane ring, while the other metaboli...

CONTEXT Flow cytometric immunophenotyping is a useful ancillary tool in the diagnosis and subclassification of acute myeloid leukemias (AMLs). A recent study concluded that CD64 is sensitive and specific for distinguishing AMLs with a monocytic component (ie, AML M4 and AML M5) from other AML subtypes. However, in that study, the intensity of CD64 was not well defined and the number of non-M4/n...

The primary alcohol/aldehyde dehydrogenase (coded by the aad gene) is responsible for butanol formation in Clostridium acetobutylicum. We complemented the non-sporulating, non-solvent-producing C. acetobutylicum M5 strain (which has lost the pSOL1 megaplasmid containing aad and the acetone-formation genes) with aad expressed from the phosphotransbutyrylase promoter and restored butanol producti...