In the female, Müllerian ducts will develop to form the uterine tubes, uterus, cervix, and the upper one-third of the vagina; in the male, they are lost. This abnormal development can lead to uterine malformations resulting from aplasia of a part of Müllerian duct. Morphological abnormalities can vary from insufficient fission of tissues causing bicornuate uterus, double uterus or preserved ute...

Background: The unique clinical syndrome of uterus didelphys, obstructed hemivagina, and ipsilateral renal anomaly is very rare and can be quite difficult to recognize because of the enormous heterogeneity in its clinical presentation. There are few long-term reports of the reproductive performance of women with this syndrome following treatment, or about the location of subsequent pregnancies....

OBJECTIVE While contraindications to Essure® placement have been provided by the manufacturer, there is no consensus on how best to remove these contraceptive devices. Here, we describe a non-hysterectomy removal of Essure® for a patient with a septate uterus (ESHRE Class IIb uterine malformation). CLINICAL CASE A 35yr old G4 P2 presented for removal of Essure® implants after three years of g...

PURPOSE Obstructed hemivagina and ipsilateral renal anomaly (OHVIRA) syndrome is a rare syndrome characterized by Müllerian duct and renal anomalies. It is usually regarded as a disease of adolescence; however, due to a number of possible problems, the management of patients before puberty should not be overlooked. We assessed the clinical course of prepubertal patients to propose appropriate m...

Apoptosis or programmed cell death is a major mechanism underlying morphogenetic events that sculpt the developing embryo. Prominent examples of cell death during vertebrate development include refinement of the immune system, specification of neuronal projections, formation of digits, and tail resorption during amphibian metamorphosis (see Jacobson et al., 1997). Müllerian duct regression is a...

OBJECTIVE To estimate the prevalence of uterine müllerian duct anomalies in a general population. DESIGN Cross-sectional study. SETTING University hospital in collaboration with the Danish Civil Registry. PATIENT(S) A total of 1,654 women randomly recruited from a general population; 686 women were eligible and accepted inclusion (429 pre- and 257 postmenopausal). Saline contrast sonohyst...

Müllerian duct regression is a complex process which involves the AMH signalling pathway. We have previously demonstrated that besides AMH and its specific type II receptor (AMHRII), BMPR-IA and Smad5 are two essential factors implicated in this mechanism. Mothers against decapentaplegic homolog 4 (Smad4) is a transcription factor and the common Smad (co-Smad) involved in transforming growth fa...

ObjectiveAccessory cavitated uterine mass (ACUM) is characterized by an endometrium-lined cavity surrounded myometrium, usually at the level of round ligament lateral to otherwise normally-shaped uterus [1]. Etiology likely congenital, possibly related gubernaculum dysfunction [2].CaseTwo cases ACUM are presented, describing a rare but important entity in workup dysmenorrhea and pelvic pain. Ou...

Herlyn–Werner–Wunderlich syndrome (HWWS) is a congenital Müllerian duct anomaly characterized by uterine didelphys, obstructed hemivagina, and ipsilateral renal agenesis. Little is reported about spinal deformity associated with this syndrome. This study presents a case of scoliosis occurring in the setting of HWWS and explores the possible association between the 2 diseases. A previously unrep...