Lysine methylation of histones and non-histone proteins has emerged in recent years as a posttranslational modification with wide-ranging cellular implications beyond epigenetic regulation. The molecular interactions between lysine methyltransferases and their substrates appear to be regulated by posttranslational modifications surrounding the lysine methyl acceptor. Two very interesting exampl...

 This study was carried out to investigate the apparent digestibility coefficients (ADCs) value of protein, amino acid and energy and body amino acid composition of rainbow trout fed solvent extracted soybean meal (SBM) and full-fat soybean meal (FFS) partly replacing fish meal (FM) in diets. Five iso nitrogenous (average 50.36% crude protein) and energetic (4294 kcal/kg total energy) diets wer...

Fibroblasts grown in tissue culture from the skin of normal subjects have lysine-ketoglutarate reductase activity (lysine: alpha-ketoglutarate: triphosphopyridine nucleotide (TPNH) oxidoreductase (epsilon-N-[L-glutaryl-2]-L-lysine forming)). The activity of the enzyme is considerably reduced in the skin fibroblasts grown from three siblings with hyperlysinemia. The high concentrations of lysine...

Two experiments were conducted to investigate whether the utilization of lysine in growing pigs is affected by the level of excess protein in the diet. Nine lysine-deficient diets containing 100, 200 or 300 g crude protein/kg and between 1.2 and 6.8 g ileal digestible lysine/kg were prepared. In the first experiment the apparent ileal digestibility of lysine in three of the nine diets was deter...

In comparison to other pseudomonads, Pseudomonas aeruginosa grows poorly in L-lysine as a sole source of nutrient. In this study, the ldcA gene (lysine decarboxylase A; PA1818), previously identified as a member of the ArgR regulon of L-arginine metabolism, was found essential for L-lysine catabolism in this organism. LdcA was purified to homogeneity from a recombinant strain of Escherichia col...

A 4-wk experiment was conducted to compare the effect of feeding crystalline lysine relative to the lysine from soybean meal (SBM) on growth performance, body chemical composition, and tissue deposition rates in nursery pigs. Thirty-six pigs were used [18 barrows and 18 gilts, 15 d old; initial BW (mean ± SEM) = 6.11 ± 0.11 kg]. Six pigs (3 barrows and 3 gilts) were killed at the beginning of t...

The microbial production of D-lysine has been of great interest as a medicinal raw material. Here, a two-step process for D-lysine production from L-lysine by the successive microbial racemization and asymmetric degradation with lysine racemase and decarboxylase was developed. The whole-cell activities of engineered Escherichia coli expressing racemases from the strains Proteus mirabilis (LYR) ...

1. The absorption of lysine and two lysine-containing dipeptides was studied in normal and cystinuric subjects by jejunal perfusion. Absorption of each dipeptide was compared with that of its constituent amino acids. 2. In normal subjects lysine was better absorbed from the dipeptide glycyl-L-lysine than from the equivalent amino acid mixture. In cystinuric patients lysine was absorbed very poo...