This article discusses the diagnostic and treatment approach to canine lymphosarcoma (LSA). Several conclusions can be drawn from the extensive body of studies on canine LSA in clinical and pathologic medicine: It is now recognized that this disease has great clinical and histologic heterogeneity; in most cases, survival can be improved with combination chemotherapy; and drug resistance is a ma...

Glyoxalase I has been purified from the livers of normal DBA/1J mice (565-fold) and mice bearing a lymphosarcoma (348-fold). There was a significant difference in the fractionation patterns of the glyoxalase I activities from the two sources. Molecular weight determinations for which Sephadex gel filtration was used were conducted on the purified enzymes. The estimated molecular weights are 48,...

The effects of 4-aminopyrazolo(3,4-d)pyrimidine (APP), alone or in combination with azaserine, thioguanine, and 6-mercaptopurine, have been tested in Ehrlich ascites carcinoma, Sarcoma 180 ascites, 6C3HED ascites lymphosarcoma, Mecca ascites lymphosarcoma, and TAS ascites carcinoma. The Ehrlich ascites carcinoma is the only tumor of this series which responds to APP. Several combinations of APP...

The differential diagnosis between visceral leishmaniasis and lymphoplasmacell polimorphocell lymphosarcoma may be difficult. One case is described in which electron microscopy allowed detection of Leishmania in the histiocytes of the spleen.