The severity of left ventricular (LV) dysfunction in rats with myocardial infarction (MI) varies widely. Because homogeneity in baseline parameters is essential for experimental investigations, a study was conducted to establish whether Doppler echocardiography (DE) could accurately identify animals with high LV end-diastolic pressure as a marker of LV dysfunction soon after MI. Direct measurem...

Methods In this community-based cohort of 28 patients free of known cardiac disease (mean age 73.8 ± 4) with preserved LV ejection fraction (mean LVEF 69.8 ± 6.4) and cardiac index (mean 3.1 ± 0.57), we assessed cardiac remodelling by cardiac MRI (concentricity (mass/ end-diastolic volume) and LV function by resting tissue Doppler imaging (TDI) performed at the septal and lateral mitral annulus...

Implantable cardioverter defibrillators (ICDs) are widely used in the prevention of ventricular arrhythmias and their efficiency to prolong life is well documented in long-term follow-up studies. On the other hand, defibrillators may cause complications, and as shown recently, the 12-year cumulative incidence of adverse events was 20% for inappropriate shock, 6% for device-related infection, an...

BACKGROUND Subclinical left ventricular (LV) diastolic dysfunction in type 2 diabetes (T2D) is a common finding and represents an early sign of diabetic cardiomyopathy. However, the relationship between LV diastolic dysfunction and the incident T2D has not been previously studied. METHODS A total of 1817 non-diabetic participants (mean age, 54 years; 48% men) from the Korean Genome and Epidem...

AIM Trastuzumab, a chemotherapeutic agent used in the treatment of breast cancer. has been shown to induce subclinical left ventricular (LV) dysfunction during a three to six month period as evidenced by strain echocardiographic examination without any change occurring in the ejection fraction of LV. The present study evaluated the presence of subclinical LV dysfunction using strain echocardiog...

We examined, in conscious dogs, the effects of acute hemorrhage on measurements of mean arterial and left ventricular (LV) pressures, LV diameters, LV dP/dt, LV dP/dt/P40, LV dP/dt/ circ, i.e., LV dP/dt divided by LV circumference, and LV dD/dt, i.e., velocity of myocardial fiber shortening. Hemorrhage (30 ml/kg) over 1 hour reduced mean arterial pressure (31 ± 4.3%), LV end-diastolic (21 ± 3.2...

OBJECTIVES Our goal was to identify the hemodynamic determinants of the mitral annulus (MA) diastolic velocities by tissue Doppler. BACKGROUND The MA diastolic velocities are promising indexes of left ventricular (LV) diastolic function. However, their hemodynamic determinants have not yet been evaluated. METHODS Ten adult mongrel dogs underwent left atrial (LA) and LV pressure measurements...

BACKGROUND Invasive studies have shown that cardiac resynchronization therapy (CRT) acutely improves left ventricular (LV) systolic performance and lowers filling pressures in a majority of patients with medically-refractory severe heart failure. Measurements included LV volume, ejection fraction, PWD early (E-wave) and atrial (A-wave) velocities, diastolic filling time (DFT), and DTI early dia...

OBJECTIVE Pericardial adipose tissue (PAT), a regional fat depot adjacent to the myocardium, may mediate the complex relation between obesity and cardiac left ventricular (LV) abnormalities. We sought to evaluate the association of PAT with echocardiographic measures of LV abnormalities in the Jackson Heart Study (JHS). RESEARCH DESIGN AND METHODS A total of 1,414 African Americans (35% men; ...

CLANCY, RICHARD L., THOMAS P. GRAHAM, JR., JOHN Ross, JR., EDMUND H. SONNENBLICK,AND EUGENE BRAUNWALD. InJuence of aortic pressure-induced homeometric autoregulation on myocardialperformance. Am. J. Physiol. 214(5) : 1186-l 192. 1968.The alteration in left ventricular (LV) performance following aortic pressure-induced homeometric autoregulation, defined by a fall in LV end-diastolic pressure af...