The inflammatory response and influence of T cell depletion on the pathogenesis of an experimental Legionella infection were studied. A/J mice were infected with 10(6) CFU of Legionella pneumophila intratracheally. With this dose all infected animals survived the infection and bacteria were cleared from lung, spleen, liver, and kidney within 10 to 11 days, leaving no residual changes in the aff...

Coronavirus disease (COVID-19), caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), has become a pandemic and huge burden to healthcare systems worldwide. One of the characteristic symptoms COVID-19 is asymptomatic hypoxemia, also called happy hypoxia, silent or hypoxemia. Patients with hypoxemia often have no subjective symptoms, such as dyspnea, even though judged objectiv...

conclusions in patients with liver cirrhosis, when there is evidence of severe pulmonary disease without proper response to treatment, the possibility of invasive pulmonary fungal infection should be considered. introduction invasive pulmonary aspergillosis (ipa) is a fatal disease usually occurring in patients with neutropenia resulted from chemotherapy for malignancy. the other risk factors i...

INTRODUCTION Antibiotics are used to treat bacterial infections by killing the bacteria or inhibiting their growth, but resistance to antibiotics can develop readily. The discovery that bacterial quorum-sensing regulates bacterial virulence as well as the formation of biofilms opens up new ways to control certain bacterial infections. Furanone compounds capable of inhibiting bacterial quorum-se...

BACKGROUND It is incompletely understood how cigarette smoke (CS) exposure affects lung mucosal immune responses during viral respiratory infections. B cell activating factor belonging to the tumor necrosis factor family (BAFF) plays an important role in the induction of secretory immunoglobulin A (S-IgA) which is the main effector of the mucosal immune system. We therefore investigated the eff...

Although mycobacterial infections are more frequent in lung transplant recipients than in other solid organ recipients only occasional reports of infection from atypical Mycobacteria have been reported in patients receiving lung transplantation. We present a case of pleural and cutaneous infection due to Mycobacterium fortuitum in a double-lung transplant recipient. The infection was rapidly re...

Abstract Cell-associated mucin 1(MUC1/Muc1) is a component of the mucus barrier in respiratory tract that acts as physical and signaling molecule. Our prior work shows MUC1 expression increased during influenza virus (IAV) infection human airway epithelial (HAE) cultures vitro. Here we further detail patterns report IAV-induced cytokines, including type I interferons (IFNs), trigger low-molecul...

Abstract Immunity is a balance of maximal pathogen defense with minimal host damage. Inhibitory immune receptors are important for maintaining this balance. We recently identified elevated levels leukocyte-associated immunoglobulin (Ig)-like receptor protein1 (LAIR1), an inhibitory receptor, in cutaneous lymphoma patients, whom invasive Staphylococcus aureus (S. aureus) infections frequent. the...

2-18F-fluorodeoxysorbitol (18F-FDS) has been shown to be a promising agent with high selectivity and sensitivity in imaging bacterial infection. The objective of our study was to validate 18F-FDS as a potential radiopharmaceutical for imaging bacterial infection longitudinally in the lung. Methods: Albino C57 female mice were intratracheally inoculated with either live or dead Klebsiella pneumo...