Peptide receptor radionuclide therapy (PRRT), developed over the last two decades, is carried out using radiopharmaceuticals such as 90Y-DOTA-Tyr3-octreotide and 177Lu-DOTA-Tyr3-octreotate (177Lu-Dotatate). These radiocompounds are obtained by labeling a synthetic somatostatin analog with a β-emitting radioisotope. The compounds differ from each other in terms of their energetic features (due t...

OBJECTIVES Gallium-68 (Ga-68) is an ideal research and hospital-based PET radioisotope. Currently, the main form of Ga-68 radiopharmaceutical that is being synthesised in-house is Ga-68 conjugated with DOTA based derivatives. The development of automated synthesis systems has increased the reliability, reproducibility and safety of radiopharmaceutical productions. Here we report on our three ye...

Objective(s): Gallium‐68 (Ga‐68) is an ideal research and hospital‐based PET radioisotope. Currently, the main form of Ga‐68 radiopharmaceutical that is being synthesised in‐house is Ga‐68 conjugated with DOTA based derivatives. The development of automated synthesis systems has increased the reliability, reproducibility and safety of radiopharmaceutical productions. Here we report on our three...

High somatostatin receptor expression on the cell membrane of succinate dehydrogenase mutation-related pheochromocytoma and paraganglioma provides a potential target for imaging and therapy. (68)Ga-DOTATATE positron emission PET/CT may represent a new gold standard for staging pheochromocytoma/paraganglioma and have future therapeutic implications.

Mazur [8] has introduced the concept of visible elements in the Tate-Shafarevich group of optimal modular elliptic curves. We generalized the notion to arbitrary abelian subvarieties of abelian varieties and found, based on calculations that assume the BirchSwinnerton-Dyer conjecture, that there are elements of the Tate-Shafarevich group of certain sub-abelian varieties of J0(p) and J1(p) that ...

We classify the possible Mumford-Tate groups of polarizable rational Hodge structures.

We prove that for abelian varieties with semistable ordinary reduction the p-adic Mazur-Tate height pairing is induced by the unit root splitting of the Hodge filtration on the first deRham cohomology.

Abstract Background With increasing clinical demand for gallium-68, commercial germanium-68/gallium-68 ([ 68 Ge]Ge/[ Ga]Ga) generators are incapable of supplying sufficient amounts the short-lived daughter isotope. In this study, we demonstrate a high-yield, automated method producing multi-Curie levels [ Ga]GaCl 3 from solid zinc-68 targets and subsequent labelling to produce clinical-grade Ga...