BACKGROUND Patients with locally advanced non-small-cell lung cancer (LA-NSCLC) have poor prognosis despite several multimodal approaches. Recently, low-dose fractionated radiotherapy concurrent to the induction chemotherapy (IC-LDRT) has been proposed to further improve the effects of chemotherapy and prognosis. Until now, the predictive value of metabolic response after IC-LDRT has not yet be...

The hyper-responsiveness of plasma cortisol to vasopressin has been reported in patients with ACTH-independent bilateral macronodular adrenocortical hyperplasia (AIMAH) and in certain cases of Cushing's adenomas with overexpression of V1a receptors in the adrenal gland. We previously reported a high prevalence of the adrenal hyper-responsiveness of plasma cortisol to vasopressin (vasopressin re...

Abstract Background and Aims Kidney transplant recipients (KTRs) were advised to tightly adhere government recommendations curb the spread of SARS-CoV-2 because a high risk morbidity mortality decreased immunogenicity after vaccination. The aim this study was analyze change in adherence preventive measures vaccination awareness antibody response, evaluate effectiveness these measures. Method Qu...

Abstract Background The low carbohydrate, high fat ketogenic diet can be an effective anticonvulsant treatment in some pediatric patients with pharmacoresistant epilepsy. Its mechanism(s) of action, however, remain uncertain. Direct sampling cerebrospinal fluid before and during metabolic therapy may reveal key changes associated differential clinical outcomes. We characterized the relationship...

background: poor ovarian response to controlled ovarian stimulation is one of the most important interest points in assisted reproduction. mild ovarian stimulation seems to be preferable to high dose of fsh regimens in women with a history of poor ovarian response in previous protocol. clomiphene citrate and letrozole alone or in combination with fsh have been used in mild ovarian stimulation p...

PURPOSE Agreement across methods for identifying students as inadequate responders or as learning disabled is often poor. We report (1) an empirical examination of final status (post-intervention benchmarks) and dual-discrepancy growth methods based on growth during the intervention and final status for assessing response to intervention; and (2) a statistical simulation of psychometric issues ...

Interindividual variability in low density lipoprotein (LDL) cholesterol (LDL-C) response during treatment with statins is well documented but poorly understood. To investigate potential metabolic and genetic determinants of statin responsiveness, 19 patients with refractory heterozygous familial hypercholesterolemia were sequentially treated with placebo, atorvastatin (10 mg/d), bile acid sequ...

Different inbred and congenic resistant strains of mice were immunized with staphylococcal exfoliative toxin A (ETA). In antibody responses measured in sera of mice by a passive hemagglutination technique, A/J, DBA/2, BALB/c, B10A, B10D2, B10S, and A.SW were high responders. C57BL/10 (B10), A.BY, and DBA/1 were low responders. The congenic C3H/HeJ and C3H.SW mice were, respectively, high and lo...