BACKGROUND AND OBJECTIVES To evaluate the feasibility, toxicity and preliminary results of a potentially less toxic variant of the MOPPEBVCAD chemotherapy regimen for advanced Hodgkin's disease: MOPPEBVCyED, in which cyclophosphamide and etoposide replace lomustine and melphalan, respectively, with the remaining components being unaltered. DESIGN AND METHODS The study was multicenter, prospec...

PURPOSE To review our experience with pre-radiation chemotherapy for malignant glioma. METHODS Consecutive adults with newly diagnosed glioblastoma, anaplastic astrocytoma, anaplastic oligodendroglioma and anaplastic mixed glioma with a Karnofsky Performance Score of 60 or greater were treated with one cycle of procarbazine, lomustine and vincristine or lomustine alone, prior to radiation. Co...

Studies were carried out in 2005 and 2006 raing seasons at four locations (Abakaliki, Ezzamgbo, Ikwo and Okposi) within the Abakaliki Agro-ecological zone of southeastern Nigeria, to determine their suitability for the production of lettuce. The measurements included weather elements, soil physico-chemical propertiesand crop growth and yield. The data collected were subjected to statistical ana...

Angiogenesis is one of the classic and diagnostic features of glioblastoma. These newly formed blood vessels are typically tortuous, forming vascular glomeruli, and they are notable for the lack of the tight junctions and complete pericyte coverage. This leads to peritumoral edema and extravasation of intravenous contrast on computed tomography or magnetic resonance imaging. Because angiogenesi...

1 Department of Cancer Medicine, Peter MacCallum Cancer Centre, East Melbourne, VIC, Australia, 2 Department of Pathology, University of Melbourne, Parkville, VIC, Australia, 3 Department of Medicine, St Vincent’s Hospital, University of Melbourne, Fitzroy, VIC, Australia, 4 Sir Peter MacCallum Department of Oncology, University of Melbourne, East Melbourne, VIC, Australia, 5 Molecular Oncology...

A revolutionary approach to air defense has been extensively evaluated recently. The approach is a new Cooperative Engagement Capability (CEC) that allows combat systems to share unfiltered sensor measurements data associated with tracks with rapid timing and precision to enable the battlegroup units to operate as one. The CEC system and the program for Fleet introduction are described. Further...

1 Monash Institute of Pharmaceutical Sciences, Monash University, Parkville, VIC, Australia, 2 Centre for Biomedical Research, Burnet Institute, Melbourne, VIC, Australia, 3 Department of Immunology, Alfred Medical Research and Education Precinct, Monash University, Melbourne, VIC, Australia, 4 Department of Surgery Austin Health, University of Melbourne, Heidelberg, VIC, Australia, 5 CHIRI Bio...

BACKGROUND It is controversial if distant recurrence of glioblastoma is more common after temozolomide (TMZ) concurrent with radiotherapy (RT). Optimal therapy for patients with recurrent disease after RT/TMZ is unclear. Our purpose was to evaluate recurrence patterns in glioblastoma and the effect of treatment at recurrence upon survival. METHODS We performed a retrospective review of 67 pat...