BACKGROUND Transversus abdominis plane (TAP) block and local anaesthetic wound infiltration can provide effective pain relief at the wound site after surgery. However, the relative efficacy of two techniques for postoperative analgesia remains controversial. METHODS We searched PUBMED, EMBASE and CENTRAL databases for randomized controlled trials (RCTs) comparing TAP block with wound infiltra...

We measured total and free plasma concentrations of ropivacaine following high-volume, high-dose local infiltration analgesia in 19 patients aged 65 years or over undergoing unilateral total hip arthroplasty. The patients received 180 ml ropivacaine 0.2% (360 mg), which was injected into the deep and peri-capsular tissues, the gluteal muscles and fascia lata, and the subcutaneous tissues and sk...

OBJECTIVE To analyze the effect of infiltration of local anesthetics on postoperative pain relief. DESIGN Prospective randomized double-blind trial. Setting. University Teaching Hospital in Barbados, West Indies. PATIENTS Patients undergoing total abdominal hysterectomy. Interventions. Patients were randomly allocated into one of four groups according to the wound infiltration: 1) preoperat...

Objective: To compare postoperative analgesia after wound infiltration with ropivacaine alone and dexmedetomidine in spine fixation surgeries prosthesis. This is aprospective randomized double-blind clinical trial.
 Methods: A total of 60 patients were recruited this study based on inclusion exclusion criteria. Written informed consent was obtained from every patient. Patients by computer-...

BACKGROUND Liposome bupivacaine is a novel formulation of the local anesthetic bupivacaine, designed to provide prolonged postsurgical analgesia. This analysis examined pooled efficacy data as reflected in cumulative pain scores from 10 randomized, double-blind liposome bupivacaine clinical studies in which the study drug was administered via local wound infiltration. METHODS A total of 823 p...

Background: Post-operative pain and prosthetic joint infections are two crucial impediments in providing a good quality of life after surgery. Aims Objectives: In this study, we evaluated the efficacy local infiltrative anesthesia (LIA) total knee arthroplasty (TKA) to study associated complications. Materials Methods: The present was conducted over 2 years. All patients who underwent replaceme...