Spermine penetrates the mitochondrial matrix at significant rates which increase sharply and non-ohmically with membrane potential. In this respect, spermine uptake is qualitatively similar to that of other cations whose electrophoretic transport has been studied in mitochondria. At 200 mV and 1 mM spermine, the observed rate of spermine uptake was about 7 nmol x mg-1 x min-1, and the rate cons...

There are several examples of heuristic rules first proposed from empirical observation, which eventually earned physicochemical validity after the fundamental derivation of a posteriori. This may be the case of Sherwood’s plot – for which a sound rationalization from first principles, entailing enthalpy and mass balances, is provided here; it applies to (fine) chemicals undergoing concentr...

The present work describes, the reaction between disodium salt of 1,3-dihydroxybenzene (in situ formation) and propargyl bromide was carried out in a solid-liquid biphasic phase transfer catalytic system at 50°C. Higher selectivity of the bis-derivative (1,3-bis(prop-2-ynyloxy)benzene) was obtained under solid-liquid PTC condion. The conversion of propargyl bromide of more than 99% was achieved...