The action of ruthenium red (RR) on Ca" loading by and Ca" release from the sarcoplasmic reticulum (SR) of chemically skinned skeletal muscle fibers of the rabbit was investigated . Ca" loading, in the presence of the precipitating anion pyrophosphate, was monitored by a light-scattering method . Ca" release was indirectly measured by following tension development evoked by caffeine . Stimulati...

The problem of diffusive bond dissociation in a double well potential under application of an external force is scrutinized. We compute the probability distribution of rupture forces and present a detailed discussion of the influence of finite rebinding probabilities on the dynamic force spectrum. In particular, we focus on barrier crossing upon extension, i.e., under linearly increased load, a...

In many sliding systems consisting of solid object on a solid substrate under dry condition, the friction force does not depend on the apparent contact area and is proportional to the loading force. This behaviour is called Amontons' law and indicates that the friction coefficient, or the ratio of the friction force to the loading force, is constant. Here, however, using numerical and analytica...

Due to the relative infancy of Parkour there is currently a lack of empirical evidence on which to base specific technique instruction upon. The purpose of this study was to compare the ground reaction forces and loading rates involved in two Parkour landing techniques encouraged by local Parkour instructors and a traditional landing technique recommended in the literature. Ten male participant...

In this paper, the plastic limit load of cylindrical shells with opening subject to combined bending moment and axial force are found by finite element method using ANSYS suite of program. The effect of various parameters such as the geometrical ratios of shell and the shape, size, axial and angular position of the opening on the limit load of cylindrical shells under various loading conditions...

Loading of dental implants immediately after placement is an important attribute for the patients receiving the implants, but may induce a failure in the osseointegration of the implant. Even though the loading required to induce such failures is currently unknown, it is estimated that the osseointegration may fail if an implant is luxated in bone by more than 50 μm. Therefore, the ability to m...

The interaction of the a5b1 integrin and its ligand, fibronectin (FN), plays a crucial role in the adhesion of cells to the extracellular matrix. An important intrinsic property of the a5b1/FN interaction is the dynamic response of the complex to a pulling force. We have carried out atomic force microscopy measurements of the interaction between a5b1 and a fibronectin fragment derived from the ...

Mechanical behavior of two-layer metal laminate structures under low-speed impact loading was investigated experimentally and numerically. The experimental results were just used for validation of numerical results. Then numerical modeling was used to study the behavior of metal laminates in details. The mechanical behavior of the metal laminate structures under impact loading was found to be d...

Cyclic compressive force is an important mechanical stimulus on periodontal ligament (PDL). The differential expression of genes in PDL cells is thought to be involved in the remodeling of periodontal tissues subjected to mechanical stress. However, little is known about differentially expressed genes in PDL cells under cyclic compressive force. In our study, human PDL cells were subjected to 4...

objective: in this paper, finite element model of the l4 vertebra subjected to combination of compression and flexion loading in isotropic and anisotropic cases is investigated. methods: in both cases, the vertebra is considered homogeneous. also, the body of vertebra is divided to cancellous and cortical sections in anisotropic model, but the process is assumed isotropic such as isotropic mode...