Effects of four levels of dietary linoleic acid (LA), an n-6 fatty acid, and four levels of alpha-linolenic acid (LNA), an n-3 fatty acid, and their interactions on immune responses in growing layer hens were studied. Immune responses were induced by injection with keyhole limpet hemocyanin (KLH) or Mycobacterium butyricum particles at 35 d of age. Antibody (Ab) responses were measured until 21...

EGSs (external guide sequences) are short antisense oligoribonucleotides that elicit RNase P-mediated cleavage of a target mRNA, which results in inhibition of gene expression. EGS technology is used to inhibit expression of a wide variety of genes, a strategy that may lead to development of novel treatments of numerous diseases, including multidrug-resistant bacterial and viral infections. Suc...

Low biological activity and inefficient targeted delivery in vivo have hindered RNA interference (RNAi)-based therapy from realising its full clinical potential. To overcome these hurdles, progresses have been made to develop new technologies optimizing oligonucleotides chemistry on one hand and achieving its effective delivery on the other hand. In this report, we achieved, by using the electr...

BACKGROUND MicroRNAs (miRs) are small noncoding RNAs that posttranscriptionally control gene expression. Small-animal studies suggest that miRs might offer novel therapeutic targets in cardiovascular diseases such as cardioprotection of murine hearts after myocardial infarction via miR-92a inhibitors. Because the functional benefits of miR-92a inhibitors in larger preclinical models are not kno...

A b s t r a c t Keywords: Cascode Topology Low Noise Amplifier Noise Figure Particle Swarm Optimization Design of a LNA is a complex process. Because it involves various parameters and needs complex trade-offs. This paper presents an optimized design of a low noise amplifier (LNA) using particle swarm optimization (PSO) technique. The proposed LNA has a cascode structure with inductive source d...

A CMOS low-noise amplifier (LNA) and mixer for a GPS front end is described. At 1.586Ghz the LNA minimum noise figure (NF) is 2.8dB, input third order intercept point (IIP3) is 2.45dB and forward gain is 30dB. With a 1.573Ghz local oscillator (LO) and a 1.586Ghz RF input the mixer minimum NF is 6.1dB, IIP3 is 12dB and a conversion gain of -3dB. The LNA and mixer consume 58mW of power from a 1.8...

This paper proposes a wideband common-gate LNA using capacitive feedback. The transconductance of the proposed LNA can be enlarged and noise figure can be improved while the conventional common-gate LNA has to use a smaller transconductance for the input impedance matching. In the experimental results using a 0.18-μm CMOS technology, the gain is 13.4 dB, NF is 2.7 dB, IIP3 is −7 dBm at 0.8GHz, ...

MicroRNAs are dysregulated in a setting of heart disease and have emerged as promising therapeutic targets. MicroRNA-34 family members (miR-34a, -34b, and -34c) are up-regulated in the heart in response to stress. In this study, we assessed whether inhibition of the miR-34 family using an s.c.-delivered seed-targeting 8-mer locked nucleic acid (LNA)-modified antimiR (LNA-antimiR-34) can provide...

Two unusual reactions involving the 5-hexenyl or the 6-heptenyl radical cyclization of a distant double bond at C4' and the radical center at C2' of the ribofuranose ring of thymidine have been used as key steps to synthesize North-type conformationally constrained cis-fused bicyclic five-membered and six-membered carbocyclic analogues of LNA (carbocyclic-LNA-T) and ENA (carbocyclic-ENA-T) in h...