BACKGROUND In Canada, there is a dose cap for weight-based treatment with low-molecular-weight (LMW) heparins. OBJECTIVE To review whether capping of LMW heparin doses is warranted for patients with obesity. METHODS English-language publications concerning the use of LMW heparin in Canada were reviewed, and the literature regarding use of these drugs at treatment doses in patients with obes...

Topological defects easily form in liquid crystals (LCs) as a result of frustrations in spatially dependent anisotropic molecular ordering, and have been regarded as promising tools for facilitating manipulation of relatively large non-LC materials such as colloids. However, it remains unclear whether low-molecular-weight (LMW) impurities that do not aggregate or self-assemble in bulk LCs becau...

We prepared self-standing chemically cross-linked hydrogels from 1,3-?-d-glucan (Mw = 2.0 × 105) and 1,3-?-d-glucans (low-molecular-weight (LMW): Mw 105, high-molecular-weight (HMW): 1.0 106), using ethylene glycol diglycidyl ether (EGDGE) as a cross-linker. Uniaxial compressive tests cylindrical of the glucans were conducted. Both LMW-1,3-?-d-glucan highly deformable shape-deformable; they cou...

Staircase electrophoresis (SCE) in polyacrilamide gels was used to analyze the stable low-molecular weight (LMW) RNA profiles of several propane and butane oxidizing bacteria belonging to different species and genera. Differences in the number and distribution of the RNA bands in these profiles allowed us to differentiate among them. Congruent results were found between the established classifi...

The purpose of this study was to analyze the expression of B cell growth factor (BCGF) receptors and to elucidate the biologic effects of biochemically purified natural BCGF at the B cell precursor stage of human B lineage lymphoid differentiation. The specific binding of radioiodinated high-mol-wt BCGF (125I-HMW-BCGF) and low-molecular-wt BCGF (125I-LMW-BCGF) to fresh marrow blasts from B cell...

BACKGROUND Because of the risk of accumulation of anticoagulant effect, it has been suggested that patients with a creatinine clearance of 30 mL/min or less (< or =0.50 mL/s) should be excluded from treatment with low-molecular-weight (LMW) heparin, or have anti-factor Xa heparin level monitoring performed. OBJECTIVE To assess the appropriateness of this recommendation. METHODS We performed...

Inputs of low molecular weight carbon (LMW-C) to soil - primarily via root exudates- are expected to be a major driver of microbial activity and source of stable soil organic carbon. It is expected that variation in the type and composition of LMW-C entering soil will influence microbial community composition and function. If this is the case then short-term changes in LMW-C inputs may alter pr...

Biokinetics data of lung-administered PEI F25-LMW/siRNA polyplexes within different lung compartments are presented. Thereby, at three different timepoints (1 h, 3 h, 8 h), the data was determined by calculations to the 32P-radioactivity in the whole mouse body. Additionally, data was optimized to the available PEI F25-LMW/siRNA polyplexes in the target organ and therefore normalized to the sum...

Brain accumulation of soluble amyloid-β oligomers (AβOs) has been implicated in synapse failure and cognitive impairment in Alzheimer's disease (AD). However, whether and how oligomers of different sizes induce synapse dysfunction is a matter of controversy. Here, we report that low-molecular-weight (LMW) and high-molecular-weight (HMW) Aβ oligomers differentially impact synapses and memory. A ...

BACKGROUND Advanced glycation end products (AGEs) have biological properties that may contribute to the premature cardiovascular mortality of haemodialysis patients. This study examines the hypothesis that low molecular weight forms of fluorescent AGEs (LMW fluorescence) predict mortality in haemodialysis patients. METHODS The LMW fluorescence was measured in 85 patients treated with chronic ...