Dextromethorphan (DM), an antitussive agent, has been shown to have anti-inflammatory and immunomodulatory effects in vitro. Thus, the aim of this study was to evaluate the effects of LK-3, an analog of DM, on sepsis induced by intravenous (i.v.) administration of lipopolysaccharide (LPS; 10 mg/ kg) in anesthetized Wistar rats. Results demonstrated that post-treatment with LK-3 (4 mg/kg, i.v.) ...

A comparative study of the Na+-stimulated adenosine triphosphatase system in high potassium (HK) and low potassium (LK) sheep red cell membranes was carried out. For HK:LK activity, the approximate ratios were as follows: 10 for Na+-ATPase, 13 for Na+, K+-ATPase, and 2.7 for [%+ ADP-ATP exchange activity; the ratio of Na+-stimulated membrane phosphorylation was approximately 7. With Na+ present...

This paper addresses the problem of extending the formulae-as-types principle to classical logic. More precisely, we introduce a typed lambda-calculus (λ-LK→) whose inhabited types are exactly the implicative tautologies of classical logic and whose type assignment system is a classical sequent calculus. Intuitively, the terms of λ-LK→ correspond to constructs that are highly non-deterministic....

(1) Give a purely combinatorial definition of the Floer cochain complex (CF (L0, L1), ∂) over ΛZ2 . In particular, prove that ∂ 2 = 0. (2) Now do the same, but over ΛK where K is an arbitrary field (not necessarily of characteristic 2). (3) How far can the conditions on the Li be relaxed? Can they be immersed curves, or nullhomotopic curves? (4) More generally, let L0, . . . , Lk be transversel...

The kinetic characteristics of the Na:K pump in high potassium (HK) and low potassium (LK) goat red cells were investigated after altering the intracellular cation concentrations. At low concentrations of intracellular K (K(c)), increasing K(c) at first stimulates the active K influx in HK cells, but at higher K(c) the pump is inhibited. These results suggest that in HK cells K(c) acts both at ...

Antitumor prodrug irinotecan is used for a variety of malignancies such as colorectal cancer. It is hydrolyzed to the metabolite, 7-ethyl-10-hydroxycamptothecin (SN-38), which exerts its antineoplastic effect. Several human and rodent carboxylesterases are shown to hydrolyze irinotecan, but the overall activity varies from enzyme to enzyme. This report describes a novel mouse liver and kidney c...

The mathematical basis of the hypothesis that type-2 topoisomerases recognize and act at specific DNA juxtapositions has been investigated by coarse-grained lattice polymer models, showing that selective segment passages at hooked juxtapositions can result in dramatic reductions in catenane and knot populations. The lattice modeling approach is here extended to account for the narrowing of vari...

The mathematical basis of the hypothesis that type-2 topoisomerases (topo II) recognize and act at specific DNA juxtapositions was investigated by coarse-grained lattice and continuum wormlike chain models, showing that selective segment passages at hooked juxtapositions can result in dramatic reductions in catenane and knot populations. The lattice modeling approach has recently been extended ...