A 39-year-old male had a stomachache for 10 days before abnormal liver function tests were detected by local doctor. Then, he was referred to us and admitted our hospital examination treatment of elevated transaminases. He taken benzbromarone treat his hyperuricemia seven months, we diagnosed him with benzbromarone-induced injury. After the termination benzbromarone, finally recovered from illn...

In the current research, rats will be given paracetamol (hepatotoxic), and hydoethanol (HEESV) extract of leaves Sida veronicaefolia tested to see how well it protects rats' livers from damage caused by paracetamol. Liver function tests serum profiles were used provide an estimate hepatoprotective effects HEESV at a dose 500 mg/kg. According findings, extracts chosen plant not only strong impac...

Studies were made on the effects of in vivo administration of anti-CD4 mAb, anti-CD8 mAb, or a combination of both mAbs on multiplication of bacteria, the levels of serum transaminases, and mortality in mice infected with Listeria monocytogenes. Results showed that in sublethal infection, CD8+ cells enhanced the peak of bacterial multiplication and liver cell necrosis, and CD4+ cells suppressed...

The current study was conducted to evaluate the possible modulating efficacy of prolonged oral administration of rhubarb extract against gamma irradiationinduced some biochemical disorders in male rats. Rhubarb extract was orally administrated at a concentration of 100 mg/kg body wt daily for 21 days before irradiation at a single dose of 7 Gy and for 7 days post exposure. Transaminases (AST & ...

The current study was designed to investigate the anti-inflammatory effect of salidroside (SDS) and the underlying mechanism by using lipopolysaccharide (LPS)-stimulated RAW 264.7 macrophages in vitro and a mouse model of binge drinking induced liver injury in vivo. SDS downregulated protein expression of toll-like receptor 4 (TLR4) and CD14. SDS inhibited LPStriggered phosphorylation of LPS-ac...

A 17-year-old male with type 1 diabetes mellitus (T1DM) presented to clinic with elevated transaminases and a positive antinuclear antibody (ANA) screen. Due to concern for autoimmune hepatitis, a liver biopsy was performed which revealed Mauriac syndrome. This case report is the second known description of a child with Mauriac syndrome presenting with positive autoimmune markers.

BACKGROUND Hepatitis is a liver inflammation caused by different agents and remains a public health problem worldwide. Medicinal plants are an important source of new molecules being considered for treatment of this disease. Our work aims at evaluating the hepatoprotective properties of Neoboutonia velutina, a Cameroonian medicinal plant. METHODS The aqueous extract has been prepared using ph...

Propylthiouracil- (PTU-) induced hepatotoxicity is rare but potentially lethal with a spectrum of liver injury ranging from asymptomatic elevation of transaminases to fulminant hepatic failure and death. We describe two cases of acute hepatic failure due to PTU that required liver transplantation. Differences in the clinical presentation, histological characteristics, and posttransplant managem...