The species Asteraceae Centaurea repens (Asteraceae), known as Acroptilon repens, andTalkhe in persian is used in folk medicine as an emetic, anti-epileptic, and anti-malaria herbin many parts of the world but its toxic effects have not determined yet. This study aimed toevaluate the acute and subchronic toxicity of this extract to find its possible adverse healtheffects through clinical, hemat...

The species Asteraceae Centaurea repens (Asteraceae), known as Acroptilon repens, andTalkhe in persian is used in folk medicine as an emetic, anti-epileptic, and anti-malaria herbin many parts of the world but its toxic effects have not determined yet. This study aimed toevaluate the acute and subchronic toxicity of this extract to find its possible adverse healtheffects through clinical, hemat...

olives and olive oil contain large amounts of oleuropein. this phenolic compound is responsible for theirbitter taste and pungent aroma and has been recognized as a powerful hypotensive, hypoglycemic andantioxidant agent. thus, the aim of the present study was to evaluate the antioxidant properties of oleuropein on ethanol-induced oxidative damage and to examine its beneficial effects on liver ...

The liver is susceptible to toxic effects, as it the main site of acrylamide biotransformation and detoxification. Researchers have claimed that placental growth factor (PlGF) its pathway are potentially involved in numerous diseases, including fibrosis angiogenesis. Oleuropein a natural phenolic compound with potent antioxidant effects. purpose this study was examine role PlGF potential protec...

Background: Soil and plant contamination in copper exposure causes chronic copper poisoning (CCP) in animals following the consumption of plants in these soils. Objectives: The present study was carried out on 10 clinically affected copper poisoned cases (in each season) from autumn 2015 to the end of summer 2016, in four seasons in Kerman province to evaluate the seasonal effects of CCP in she...

Acetaminophen overdose causes toxicity in liver and extrahepatic tissues. Although it is well established that cytochrome P450 enzymes play a critical role in the metabolic activation of acetaminophen, it is not yet clear whether acetaminophen toxicity in extrahepatic tissues is a consequence of hepatic biotransformation. The aim of this study was to determine whether extrahepatic acetaminophen...

Aflatoxins (AFs) are a group of highly toxic mycotoxins mainly produced by Aspergillus flavus and parasiticus, which considered natural contaminants food feed to the liver, carcinogens mutagenic. Therefore, reducing their toxicity in body organism is great importance. In this study, aqueous extract leaves was evaluated (green Tea sage) reduce caused aflatoxins. Two concentrations aflatoxins (0....

Mammalian liver consists of at least fourteen different types of cells. Hepatocytes, the most common site of toxic action, account for between 60 per cent (rat) and 85 per cent (man) of the total number of cells in the liver, or 90-95 per cent of the total weight of the liver. The reticuloendothelial cells (also called Kupffer, littoral or sinusoidal cells) only constitute 5-10 per cent of live...

In the last few months there have been three letters in The Lancet, follow-up articles in most of the national newspapers including The Times and The Sunday Times, and discussions on the Jimmy Young Show on the toxicity of herbal medicines and a potential link with liver fatality. Subsequently, rumours have been spreading as to inherent dangers in herbal prescriptions and possible restrictions ...

Toxicogenomics (TGx) is a widely used technique in the preclinical stage of drug development to investigate the molecular mechanisms of toxicity. A number of candidate TGx biomarkers have now been identified and are utilized for both assessing and predicting toxicities. Further accumulation of novel TGx biomarkers will lead to more efficient, appropriate and cost effective drug risk assessment,...