MRE is a magnetic resonance imaging (MRI)-based technology for non-invasively characterizing the biomechanical properties of tissues and may serve as a potential surrogate to invasive liver biopsies for diagnosing and staging liver fibrosis. MRE can be used to quantitatively image the direct consequence of liver fibrosisincreased stiffness of the hepatic tissue. MRE is performed following three...

Tissue and matrix stiffness affect cell properties during morphogenesis, cell growth, differentiation, and migration and are altered in the tissue remodeling following injury and the pathological progression. However, detailed molecular mechanisms underlying alterations of stiffness in vivo are still poorly understood. Recent engineering technologies have developed powerful techniques to charac...

background vitamin d deficiency is believed to cause variety of abnormalities such as liver stiffness and fibrosis. it is also shown that vitamin d deficiency may result in chronic liver disease or liver cirrhosis. in this study, we aimed to systematically review the literature wherein the relationship between vitamin d deficiency and the severity of chronic liver disease or liver cirrhosis had...

Objective: To develop a CT elastography imaging system useful for part of the human body in which ultrasound is not capable of reaching. The proposed system would measure CT modality through fusion of the stiffness mapping on the images by the tactile sensor system, improving precision of the endoscopic operation. Methods: We made some liver fibrosis phantoms of bovine skin gelatin with various...

Liver stiffness, which correlates well with liver fibrosis stage, can be measured noninvasively by transient elastography, also known as Fibroscan. The present study aimed to determine the independent factors influencing Fibroscan detection by multiple regression analysis. A total of 181 patients who required liver biopsy were enrolled. Liver stiffness measurement (LSM) was detected by Fibrosca...

NHA The Fibroscan device (Echosens) works by measuring shear wave velocity. In this technique, a 50-MHz wave is passed into the liver from a small transducer on the end of an ultrasound probe (Figure 1). The probe also has a transducer on the end that can measure the velocity of the shear wave (in meters per second) as this wave passes through the liver. The shear wave velocity can then be conv...

Introduction: MR Elastography (MRE) [1] is increasingly being used to measure tissue stiffness in different areas of the body. It has recently shown great success in the liver for the evaluation of hepatic fibrosis in patients with chronic liver diseases [2]. Patients that have had high iron concentration in their liver tissue, which leads to severely, shortened T2/T2*, can be problematic at 3....

OBJECTIVE Even after successful Kasai portoenterostomy, progressive hepatic fibrosis in postoperative patients with biliary atresia (BA) can be associated with portal hypertension and esophageal or gastric varices. Therefore, early diagnosis and close follow-up of varices are important. We investigated the correlation between the liver stiffness scores measured by FibroScan and the presence of ...

OBJECTIVE HIV/HCV co-infection is characterised by accelerated progression of liver disease. Recently, the rs12979860 C/T polymorphism in the IL28B gene has been linked to progression towards cirrhosis in HCV mono-infected patients and to treatment response of HCV-infection in HIV/HCV co-infected patients. Our aim was to clarify by non-invasive techniques if this polymorphism affects fibrosis p...