Background: Human embryonic stem cells (hESC), which are derived from the inner cell mass of the blastocysts, have been considered to be pluripotent cells. In this study we examine the differentiating potential of hESC into hepatocytes by characterization of the expression of endoderm and liver-specific genes. Methods: hESC were cultivated in suspension to form aggregates, the embryoid bodies. ...

  Purpose: To recognize affective factors in delivering X-ray contrast agents (which have high atomic number) via gallium carrier to liver or lymphatic neoplasm cells.   Materials and Methods: Since uptake of gallium by liver has been reported in numerous researches, it was bonded with a contrast media (metrizoate). X-ray imaging was done to determine geometric features of liver.   Results: Rad...

Zinc oxide (ZnO) nanoparticles have received growing attention for several biomedical applications. Nanoparticles proposed for these applications possess the potential to interact with biological components such as the blood, cells/ tissues following their administration into the body. Hence we carried out in vivo investigations in Swiss Albino Mice to understand the interaction of ZnO nanorods...

A series of tertiary sulphonamide derivatives were synthesised and evaluated for their antiproliferative activity against liver cancer cell lines (SNU-475, HepG-2, Bel-7402). Among these sulphonamides, compound 17a displayed the best anti-liver Bel-7402 cells with an IC50 value 0.32 μM. Compound could effectively inhibit tubulin polymerisation 1.27 Meanwhile, it selectively suppressed LSD1 63 n...

Bile ducts from patients with PSC are enriched in neutrophils and biliary-resident CD8 + T cells differ composition liver tissue.

Irreversible hepatic fibrosis, an excessive production and accumulation of extra cellular matrix by stellate cells in the liver, becomes a remarkable economic burden global health care system.Low therapeutic efficacy undesirable systemic effect conventional therapies limit their clinical applications to targethepatic cells.

high levels of regulated oncogen-alpha (gro-a) expression have been observed in the liver. gro-a stimulates proliferation of epithelial cells and induction of rolling and extravascular migration of neutrophils and mononuclear cells. given the above observations, this chemokine was chosen to be analyzed in freshly isolated and cultured hepatocytes. in this study, hepatocytes (2×106 cell/ml) were...

Transmission of Toxocara vitulorum Infection causes a decrease in livestock productivity and results various types diseases humans. Chickens are one the parasitic hosts toxocariasis which has potential for transmission to The main location affected by T. larval infection is liver. current study aimed analyze description histopathological changes liver broiler chickens infected L2 vitulorum. pre...