BACKGROUND Primary liver progenitor cell cancer is a rare disease entity. Current nomenclature of primary liver cancer with prominent progenitor features is not comprehensive. This study was aimed to investigate the existence of this type of primary liver cancer and characterize it immunohistopathologically based on the emerging understanding of cancer stem cell pathobiology. METHODS Surgical...

A drastic difference exists between the 5-year survival rates of colorectal cancer patients with localized and distal organ metastasis. The liver is most favorable for metastases from colorectum. Beyond liver-colon anatomic relationship, emerging evidence highlights impact immune microenvironment on Prior to cell dissemination, hepatocytes secrete multiple factors recruit or activate cells stro...

Liver cancers are characterized by high morbidity and mortality owing to few effective drugs for its treatment. Wilfortrine has several pharmacological effects, including an inhibitory effect on liver cancer cell proliferation. However, whether wilfortrine can induce liver cancer cell apoptosis has not been elucidated. We investigated the role of wilfortrine on liver cancer cell HepG2 apoptosis...

OBJECTIVE This study was designed to explore the influence of Toll-like receptor 4 (TLR4) agonist lipopolysaccharides (LPS) on liver cancer cell and the feasibility to perform liver cancer adjuvant therapy. METHODS Human liver cancer cell lines HepG2, H7402, and PLC/PRF/5 were taken as models, and the expression of TLRs mRNA was detected by real time-polymerase chain reaction method semiquant...

background: lung cancer ranks among the most common and most lethal malignancies worldwide. once vascular or lymphatic invasions occur, metastatic dissemination to distant sites is common. bone, liver, adrenals, and brain are the most frequent sites of the distant disease. in this study we present a case of squamous cell carcinoma of lung with metastasis of the left knee bursa.case presentation...

Hepatocellular carcinoma is the most common primary malignancy of the liver in adults. It is also the fifth most common solid cancer worldwide and the third leading cause of cancer-related death. Recent research supports that liver cancer is a disease of adult stem cells. From the models of experimental hepatocarcinogenesis, there may be at least three distinct cell lineages with progenitor pro...

Abstract In China, hepatocellular carcinoma (HCC) is considered a malignant tumor with poor prognosis, frequent metastasis, and high relapse rate. Telocytes (TCs) participate in tumorigenic, invasive, migratory processes by secreting functional proteins transmitting cell-to-cell information, but their functions HCC are still unknown. TC counts MMP9 expression liver cancer tissues were measured ...

The current notion that obesity is a major risk factor for the development of and the mortality associated with a subset of liver cancer is well appreciated. However, detailed mechanistic insights underlying this relationship are lacking. Better understanding of the adipose tissue-secreted miRNAs that play a potential role in defining primary liver cancer development and mediating the obesity-c...

ito cell (fat storing cell=fsc) is one of the cells which forms the liver sinusoidal wall it also forms the connective tissue of the liver. the cell was first identified in 1963 by a scientist named ito. it will get damaged due to the plasma fat increase which is resulted from a diet of corn oil 10% and fish oil 10% the damage wil be in form of fat storing cell. the fsc morphology may represent...