Objective: To report a case of lithium induced bilateral nonpitting pedal edema. Methods: The clinical data of a bipolar affective disorder patient with current episode of mania and psychotic symptoms who experienced bilateral non pitting pedal edema with lithium. Results: The patient was a 29 yr old female who developed bilateral non-pitting type pedal edema with lithium therapy with normal pl...

Lithium toxicity is known to affect multiple organ systems, including the central nervous system. Lithium levels have been used in the diagnosis of toxicity and in assessing response to management. There is evidence that nonsteroidal anti-inflammatory medications (NSAIDs) can increase lithium levels and decrease renal lithium clearance. We present a case of lithium toxicity, which demonstrates ...

Reducing the high charge potential is a crucial concern in advancing the performance of lithium-oxygen batteries. Here, for water-containing lithium-oxygen batteries with lithium hydroxide products, we find that a hydrogen peroxide aqueous solution added in the electrolyte can effectively promote the decomposition of lithium hydroxide compounds at the ultralow charge potential on a catalyst-fre...

Commercial dental lithium disilicate based glass-ceramics containing various amounts of P2O5 were synthesized. Regarding the crystallization behavior and physico-chemical properties of the glasses, the optimum percent of P2O5 was determined.as 8 %wt. Crystallization behavior of the glasses was investigated by X-ray diffraction (XRD) and differential thermal analysis (DTA). The micro-hardness a...

Lithium has been a gold standard in the treatment of bipolar disorder (BD) for several decades. Despite a general reduction in the use of lithium over the past several years, it is effective in the management of both manic and depressive episodes in BD and continues to be recommended as a first-line mood stabilizer. This review provides an overview of the pharmacology of lithium and highlights ...

Despite its virtually universal acceptance as the gold standard in treating bipolar disorder, prescription rates for lithium have been decreasing recently. Although this observation is multifactorial, one obvious potential contributor is the side effect and toxicity burden associated with lithium. Additionally, side effect concerns assuredly play some role in lithium nonadherence. This paper su...

Xenopus embryos treated with 100 mM-lithium from the 2- to 4-cell stage to the early blastula stage (4h) failed to neurulate and developed without a discernible anteroposterior axis. The internal structure of defective embryos was grossly disorganized, but immunohistochemical staining with cell-type-specific antibodies revealed differentiated nerve and muscle cells. Quantitative assay in tissue...

Since lithium causes granulocytosis in some patients, its effect upon granulocyte production was investigated using mouse marrow in the agar culture system. When lithium was added to semisolid cultures of mouse marrow, there was no stimulation of colony formation in the absence of colony-stimulating activity (CSA). In addition, lithium did not potentiate the action of already formed CSA. Howeve...

Elizur et al. (1) and Nelson and Cohen (2) found that erythrocyte lithium concentration and erythrocyte/plasma lithium ratio may be of greater diagnostic significance than is serum lithium concentration. Lyttkens et al. (3) found that certain schizophrenic patients retain more lithium intracellularly than do normal persons, which may explain why symptoms of lithium toxicity may appear in the pr...

the carrier facilitated transport of lithium picrate was studied using a series of non-cyclic polyethers containing different end groups and chain lengths through bulk liquid membrane (blm) and supported liquid membrane (slm) systems. the various membrane supports used are viz. ptfe, cellulose nitrate, and dialysis membrane and onion membrane. the amount of li+ transported depends upon the stru...