Background: BCS class II and IV drugs, which have low solubility, provide a number of challenges for formulation scientists working on oral delivery of drugs. Aims: The aim and purpose of the present work was to design a gel liquisolid tablets for Atorvastatin calcium a water insoluble drug to increase its dissolution rate there by its bioavailability. Materials and Methods: The preformulation ...

Objective: The aim of this study was to investigate the potential a liquisolid system improve dissolution rate and bioavailability nebivolol hydrochloride. Methods: Solubility determined in different nonvolatile solvents finalize best vehicle having maximum solubility. compacts were prepared using Fujicalin as carrier material, Aerosil 200 coating Polyethylene glycol 400 liquid vehicle, Croscar...

Liquisolid systems are a novel, promising platform for the production of solid dosage forms with high liquid content, i.e. dispersion drug in suitable, hydrophilic, non-volatile vehicle or drug. This technology requires conventional, but highly porous excipients (carrier and coating material appropriate ratio) able to absorb/adsorb medication, resulting both good flowability acceptable compress...

The present study aimed at the formulation of matrix tablets for colon-specific drug delivery (CSDD) system of indomethacin (IDM) by applying liquisolid (LS) technique. A CSDD system based on time-dependent polymethacrylates and enzyme degradable polysaccharides was established. Eudragit RL 100 (E-RL 100) was employed as time-dependent polymer, whereas bacterial degradable polysaccharides were ...

The objective of the present work was to obtain pH independent and improved dissolution profile for a poorly soluble drug, telmisartan using liquisolid compacts. Liquisolid compacts were prepared using Transcutol HP as vehicle, Avicel PH102 as carrier, and Aerosil 200 as a coating material. The formulations were evaluated for drug excipient interactions, change in crystallinity of drug, flow pr...