Zusammenfassung Die vorliegende Übersicht zum Biomarker „Lipoprotein(a) – Lp(a)“ wird im Rahmen der Serie Diagnostika des Zentralblatts für Arbeitsmedizin, Arbeitsschutz und Ergonomie publiziert, die sich mit dem immer häufigeren Gebrauch Bestimmung von spezifischen Markern bei sog. Manager-Vorsorgen Check-up-Untersuchungen beschäftigt. Lipoprotein(a), Lp(a), eignet grundsätzlich nicht solche V...

background: coronary artery disease (cad) is one of the leading causes of death and disability around the world. interaction between genetic and environmental factors determines susceptibility of an individual to develop coronary artery disease . lipoprotein lipase (lpl) play an important role in the metabolism of hdl-c ( high density lipoprotein cholesterol ), ldl-c (low density lipoprotein ch...

Diabetes mellitus is a complex multifarious metabolic disorder characterized by chronic hyperglycemia that requires non-stop treatment with multiple factors will reduce the risk of long-term complications and drug side effects. Streptozotocin well known for its selective pancreatic islet β-cell cytotoxicity used to induce diabetes in animals. It also interferes cellular oxidative mechanisms. Ph...

OBJECTIVE Carriers of the PCSK9 (proprotein convertase subtilisin/kexin 9) R46L genetic variant (rs11591147) are characterized by low levels of low-density lipoprotein cholesterol and a decreased risk of cardiovascular disease. We studied the impact of the R46L variant on lipoprotein size and composition. APPROACH AND RESULTS Lipoprotein size and composition were measured by nuclear magnetic ...

Over the past few years, there has been an undiminished interest on lipoprotein(a) [Lp(a)]. High Lp(a) levels have proposed as independent causal risk factor for atherosclerotic cardiovascular disease (CVD). The main question that remains to be answered, however, is potential clinical benefit of reduction. This will contribute enrichment our knowledge exact pathophysiological role this lipoprot...

the non-enzymatic carbamylation of low density lipoprotein (ldl) is a naturally occurring chemical modification of apolipoprotein b as a result of condensation between lysine residues and cyanate derived from urea. carbamylated ldl is poorly recognized by ldl receptors and initiates different processes that can be considered proatherogenic. thus, ldl carbamylation may contribute to the increase...