Abstract Context Withania coagulans (Stocks) Dunal fruits are used in the therapeutics of several ailments due to possessing potent phytoconstituents which is also traditionally for curing diabetes. Objective The present study was assessing amelioration potential phytochemicals an ethanol fruit extract W. HOMA (Homeostatic model assessment) indices and pancreatic endocrinal tissues by inhibitio...

Nitazoxanide merupakan obat pro-drug untuk tizoxanide. Obat tersebut diketahui memiliki aktivitas antivirus pada MERS-CoV. Arbidol H3N2 HA yang kesamaan struktur dengan SARS-CoV-2. Reseptor target spesifik obat-obat Anti SARS-CoV-2 saat ini adalah NSP5 (Nonstructural protein) dan ACE2 (Angiotensin-converting enzyme 2). memediasi replikasi transkripsi protein-protein virus sedangkan sebagai fasi...

With the uncontrolled spread of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), development and distribution antiviral drugs vaccines have gained tremendous importance. This study focused on two viral proteases namely main protease (M pro ) papain-like (PL human angiotensin-converting enzyme (ACE-2) to identify which these are essential for replication. We screened 102 secondary m...

BACKGROUND: Diabetes mellitus contributes to the delayed healing of wounds causes disturbance inflammatory cytokine. Tumour necrosis factor alpha (TNF-alpha) and Vascular Endothelial Growth Factor Receptor (VEGFR) both have a role in persistent inflammation associated with diabetic wounds. Ficus religiosa has developed reputation as traditional wound healer among some java people Indonesia. AIM...

The 5HT reuptake inhibiting antidepressants (SSRIs) were introduced into clinical practice in the late 1980s. From the time of their introduction a series of reports have appeared indicating that they were liable to produce motor (extrapyramidal),sideeffects (Meltzer et al., 1979; Bouchard et al., 1989; Baldwin et al., 1991), including dystonias (Brod, 1989; Reccoppa et al., 1990), dyskinesias ...

In this article, a full dynamic datadriven application system (DDDAS) is proposed for dynamically estimating a concentration plume and planning optimal paths for unmanned aerial vehicles (UAVs) equipped with environmental sensors. The proposed DDDAS dynamically incorporates measured data from UAVs into an environmental simulation while simultaneously steering measurement processes. In order to ...

Screening of " drug-like" molecule from the molecular database produced through high throughput techniques and their large repositories requires robust classification. In our work, a set of heuristically chosen nine molecular descriptors including four from Lipinski's rule, were used as classification parameter for screening "drug-like" molecules. The robustness of classification was compared w...

BACKGROUND The Ebola virus is highly pathogenic and destructive to humans and other primates. The Ebola virus encodes viral protein 40 (VP40), which is highly expressed and regulates the assembly and release of viral particles in the host cell. Because VP40 plays a prominent role in the life cycle of the Ebola virus, it is considered as a key target for antiviral treatment. However, there is cu...

The Chinese believe consuming edible bird’s nests (EBN) can increase immunity to various diseases, including Covid-19. This study attempts identify SARS COV-2-specific anti-viral and anti-inflammatory agents of EBN. We gathered samples from PubChem Protein Data Bank (PDB). Afterwards, drug likeness was examined using the Lipinski model SCFBIO online service. PASS web server analyzed bioactive l...

Background:Â Malaria is an endemic disease that can lead to death. control a threatening cause of resistance antimalarial drugs so renewable therapies are needed overcome this disease. The chemical compounds garlic have potential as agents, but the mechanism still unknown. Aim:Â This research will predict compounds' molecular in (Allium sativum) using in-silico method. Methods:Â In-silico metho...