The allergic response is initiated on the plasma membrane of mast cells by phosphorylation of the receptor for immunoglobulin E (IgE), FcεRI, by Lyn kinase after IgE-FcεRI complexes are cross-linked by multivalent antigen. Signal transduction requires reorganization of receptors and membrane signaling proteins, but this spatial regulation is not well defined. We used fluorescence localization m...

P-selectin glycoprotein ligand-1 (PSGL-1) and integrins are adhesion molecules that play critical roles in host defense and innate immunity. PSGL-1 mediates leukocyte rolling and primes leukocytes for integrin-mediated adhesion. However, the mechanism that PSGL-1 as a rolling receptor in regulating integrin activation has not been well characterized. Here, we investigate the function of lipid r...

Peroxisome proliferator-activated receptors (PPARs) are ligand-activated nuclear receptors regulating the expression of genes that control lipid and glucose homeostasis, modulating thus the major metabolic disorders predisposing to atherosclerosis and subsequent cardiovascular diseases [1]. Moreover, PPARs exert additional anti-inflammatory and lipid-modulating effects in the arterial wall, bei...

New lipid conjugates of DNA and RNA incorporating one to four [(4-dodecylphenyl)sulfonyl]phosphoramidate or (hexadecylsulfonyl)phosphoramidate groups at internucleotidic positions near the 3? 5?-end were synthesized characterized. Low cytotoxicity their ability be taken up into cells without transfection agents demonstrated. Lipid-conjugated siRNAs targeting repulsive guidance molecules a (RGMa...

Abstract The crosstalk between the immune and neuroendocrine system is critical for intestinal homeostasis gut-brain communications. However, it remains unclear how cells participate in gut sensation of hormones release response to environmental cues, such as self microbial lipids. We show here that lipid-mediated engagement invariant natural killer T (iNKT) with enterochromaffin (EC) cells, a ...