The present study was undertaken to investigate glutathione content and lipid peroxidation in rat livers after chronic inhalation of ethylene oxide. Male wistar rats were exposed to 500ppm ethylene oxide 6 hours a day 3 times a week for 13 weeks. In order to exclude the supressed gain of body weight, this study was done using pair-fed rats. Clinical investigation revealed that liver function wa...

Lipid peroxidation involves the oxidative deterioration of polyunsaturated fatty acids in biomembranes and generates a variety of aldehydic products including malondialdehyde (MDA). To demonstrate the occurrence of lipid peroxidation in biological systems, the production of MDA has been shown to be a relevant indicator. Therefore, we describe a new method for measurement of free malondialdehyde...

OBJECTIVE Our goal was to characterize the changes in maternal lipid peroxidation levels and antioxidant enzymatic activities before and after delivery. METHODS Predelivery and 1, 24, and 48 hours post-partum plasma concentrations of malondialdehyde, erythrocyte enzyme superoxide dismutase, glutathione peroxidase and catalase were measured in uncomplicated pregnancies. RESULTS Malondialdehy...

Increased oxidative stress is the consequence of either enhanced reactive oxygen species (ROS) production or attenuated ROS scavenging capacity, resulting in tissue damage that in most instances is assessed by the measurement of lipid peroxides. In the current study, diabetes-induced lipid peroxidation in rat liver microsomal membranes was investigated by Fourier transform infrared (FT-IR) spec...

The aim of study was to assay serum copper, zinc and lipid peroxidation levels in pregnant women with and without preeclampsia. There were significant differences between systolic, diastolic blood pressures and copper, Cu/Zn ratio and malondialdehyde among two groups. There were significant differences in weight, pre-pregnancy body mass index, systolic, diastolic blood pressures and copper, Cu/...

Alzheimer's disease (AD) is an age-related neurodegenerative disorder. A number of hypotheses have been proposed to explain AD pathogenesis. One such hypothesis proposed to explain AD pathogenesis is the oxidative stress hypothesis. Increased levels of oxidative stress markers including the markers of lipid peroxidation such as acrolein, 4-hydroxy-2-trans-nonenal (HNE), malondialdehyde, etc. ar...

Abnormal lipid levels are an important risk factor in the development of atherosclerotic complications like stroke. Oxidative stress, lipid and lipoprotein Peroxidation are involved in neuronal damage induced by ischemia-reperfusion in stroke. Malondialdehyde (MDA) is widely utilized as a marker of lipid Peroxidation in state of elevated oxidative stress. The role of lipid in oxidative damage i...

Background: Early childhood caries (ECC) is an aggressive and multifactorial form of dental in children, which the biomarkers oxidative stress may increase. Objectives: This study aimed to compare salivary malondialdehyde (MDA) levels children with early caries-free (CF) children. Methods: To this end, 42 ECC CF aged 4 - 6 years, were randomly selected from kindergartens four socio-economically...

It has been reported that smokers have higher plasma malondialdehyde concentrations compared with non-smokers. However, smokers have also consistently been shown to have a lower intake of fruits and vegetables as well as lower plasma antioxidant concentrations. Since both the latter issues may well influence the malondialdehyde concentration, we wanted to investigate if the observed difference ...

BACKGROUND Free radical-mediated oxidative damage to lipids is thought to be an important process in the pathogenesis of atherosclerosis. Although previous studies have demonstrated a beneficial impact of antioxidant vitamin supplements on lipid peroxidation, the effect of dietary patterns on lipid peroxidation is unknown. METHODS AND RESULTS During the 3-week run-in period of a randomized tr...