The establishment of the intestinal microflora, and probiotic bacteria, may control the inflammatory conditions in the gut. As polyunsaturated fatty acids (PUFA) possess antimicrobial activities, they may deter the action of probiotics. We assessed whether free linoleic, gamma-linolenic, arachidonic, alpha-linolenic and docosahexaenoic acids at physiological concentrations in the growth media w...

Fig. 1. Pathway of biosynthesis and metabolism of polyunsaturated fatty acids. All mam synthesis is palmitic acid (16: 0) which can be elongated to stearic acid (18:0). Stearic a present in cells of both plants and animals. Mammalian cells lack D-12 desaturase and desaturase, the enzyme responsible for the synthesis ofa-linolenic acid (ALA; 18:3 n-3) o on their diet. Once consumed, these EFA ca...

Objective: This study investigated the association between dietary intake of PUFAs and PN in the U.S. population. Research Design and Methods: We analyzed data from NHANES 1999-2004 for adults≥ 40 years with diagnosed diabetes, an assessment of PN and reliable 24-hour dietary recall. The dietary intake of PUFAs was analyzed by PN status. Multivariate logistic regression models were used to esti...

Japanese horse chestnut (Aesculus turbinata) seed extract inhibits the activity of cyclooxygenase (COX), but its active constituents have not been identified. In the present study, COX inhibitors were isolated from the hexane extract of this seed by means of 4 steps of liquid chromatography and were identified by gas chromatography/mass spectrometry and nuclear magnetic resonance. The COX inhib...

AA: Arachidonic Acid; ALA: Alfa-Linolenic Acid; ATP: Adult Treatment Panel; BP: Blood Pressure; CVD: Cardiovascular Disease; CRP: C reactive protein; DGLA: Dihomo-γ-Linolenic Acid; DHA: Docosahexaenoic Acid; DPA: Docosapentaenoic Acid; EFA: Essential Fatty Acids; EPA: Eicosapentaenoic Acid; FA: Fatty Acid; GLA -Gama-Linolenic Acid; HDL: High Density Lipoprotein; IL: Interleukine; IR: Insulin Re...

Oomen et al (1) reported on the lack of association between -linolenic acid (ALA, 18:3n 3) consumption and the incidence of coronary artery disease in a 10-y follow-up. We believe that 2 major limitations of this study might have affected its outcome and led to the wrong conclusions. First, this study did not control for plasma concentrations of -linolenic acid; it is thus difficult to establis...

Introduction Gamma-linolenic acid (GLA) is an important conditionally essential fatty acid (EFA). GLA is an omega-6 polyunsaturated fatty acid (PUFA). The fatty acid molecule is comprised of 18 carbon atoms with three double bonds. It is also known as 18:3n-6; 6,9,12-octadecatrienoic acid; cis-6, cis-9, cis-12octadecatrienoic acid; and gamolenic acid. GLA is found naturally in the fatty acid fr...

This work studied the antioxidant and anti-colorectal cancer properties of a potential strain thraustochytrids, Schizochytrium sp. (SMKK1), isolated from mangrove leaf litter. The biomass was extracted with methanol screened for activity using six different assays. extract exhibited highest total (87.37 ± 1.22%) lowest nitric oxide radical (75.12 2.22%), increased concentration extract. methano...