Lateral diffusion in the membrane and endosomal trafficking both contribute to the addition and removal of AMPA receptors (AMPARs) at postsynaptic sites. However, the spatial coordination between these mechanisms has remained unclear, because little is known about the dynamics of AMPAR-containing endosomes. In addition, how the positioning of AMPAR-containing endosomes affects synapse organizat...

as wireless networks with high data rate get widely deployed, improving the performance of tcp over these networks plays vital role. wireless link losses have dramatic adverse impact on tcp performance due to the difficulty in distinguishing the congestion losses from wireless link losses. we first, studied the various existing bandwidth estimation algorithms over the wireless networks. in this...

Background: The link prediction issue is one of the most widely used problems in complex network analysis. Link prediction requires knowing the background of previous link connections and combining them with available information. The link prediction local approaches with node structure objectives are fast in case of speed but are not accurate enough. On the other hand, the global link predicti...

Whether human speech perception depends on a biologically based link between production and perception or whether it is best characterised as a series of acoustic, phonetic, and semantic transformations has remained an unresolved issue. We addressed this question via the use of objective brain research methods combined with advanced stimulus production methodology. We removed the contribution o...

tRNA splicing is a fundamental process required for cell growth and division. The first step in tRNA splicing is the removal of introns catalyzed in yeast by the tRNA splicing endonuclease. The enzyme responsible for intron removal in mammalian cells is unknown. We present the identification and characterization of the human tRNA splicing endonuclease. This enzyme consists of HsSen2, HsSen34, H...

The robustness of complex networks under targeted attacks is deeply connected to the resilience of complex systems, i.e., the ability to make appropriate responses to the attacks. In this article, we investigated the state-of-the-art targeted node attack algorithms and demonstrate that they become very inefficient when the cost of the attack is taken into consideration. In this paper, we made e...

INTRODUCTION Despite a substantial body of literature refuting an association between third molar eruption and crowding of the anterior dentition, the issue continues to be controversial. METHODS A survey was developed to evaluate and compare the current opinions of orthodontists (n = 393) and oral and maxillofacial surgeons (n = 458) regarding the link between third molars and the developmen...

In Alzheimer's disease (AD), the pathological accumulation of tau appears to be a downstream effect of amyloid β protein (Aβ). However, the relationship between these two proteins and memory loss is unclear. In this study, we evaluated the specific removal of pathological tau oligomers in aged Tg2576 mice by passive immunotherapy using tau oligomer-specific monoclonal antibody. Removal of tau o...

The ornamental plant trade has been identified as a key introduction pathway for plant pathogens. Establishing effective biosecurity measures to reduce the risk of plant pathogen outbreaks in the live plant trade is therefore important. Management of invasive pathogens has been identified as a weakest link public good, and thus is reliant on the actions of individual private agents. This paper ...