there exists compelling evidence that toll-like receptor 3 (tlr3) agonists can directly affect human cancer cells. the aim of this study was to investigate anti-cancer effects of tlr3 agonist in human breast cell line. we assessed potential effects of poly (a:u) on human breast cell line (mda-mb-231)  on a dose-response and time-course  basis. human breast cell line  mda-mb-231  was treated wit...

Despite the progress in cancer therapies such as chemotherapy and radiation, its eradication remains as unattainable dream for the patients and doctors. Recently, using supplementary agents such as herbal medicine with fewer side effects seems efficient and attractive. Therefore, the purpose of the present study is to investigate if the ethanolic extract of P.oleracea has cytotoxicity and apopt...

background: urtica dioica is one of the medicinal herbs with many uses in treating various diseases. in some studies, its antiproliferative and apoptotic effects on cancer cell lines have been shown. therefore, the evaluation of u. dioica effect was performed on kg-1 cell line for acute myelogenous leukemia (aml) for the first time in this study. materials and methods: kg-1 cell line was treate...

background cancer stem cells play crucial roles in resistance to therapeutic schemes and relapse of disease, so it is important to find targeted therapies that kill them selectively. breast cancer is the most common cancer in females living in all part of the world including iran and it has an important burden in public health with direct impact on patients’ families. breast cancer in young adu...

in this study, isolate sr99-ua (race 70e 128) of wheat stripe rust (puccinia striiformis west. f. sp. tritici eriks) was used to infect susceptible spring wheat (cultivar thatcher) and its near isogenic line possessing yr-18 adult-plant resistance gene. samples were taken at the flag leaf stage and observed using light, transmission and scanning electron micro-scopes. no major differences in th...

effects of culture medium containing hormonal compositions on phenotypic and chromosomal variations of sugarbeet cultured tissues were examined. experiments were carried out in different nacl levels. cytological studies were conducted on calli originated from suspension culture. hypocotyl of seven day old seedlings of the two diploid lines were cultured in ms medium containing hormonal composit...

objective(s): regarding the presence of many active biological constituents in avicennia marina, the present investigation was carried out to study cytotoxic activity of crude methanol leave extract and column chromatographic fractions of a. marina against mda-mb 231 cell line (human breast cancer cell) and hek (human embryonic kidney cell) line .   materials and methods: the anticancer activit...

background glioblastoma is a type of brain tumor with poor response to available therapies, and shows high rate of mortality. despite remarkable advancements in our knowledge about cytogenetic and pathophysiologic features of glioblastoma, current treatment strategies are mainly based on cytotoxic drugs; however, these therapeutic approaches are facing progressive failure because of the resista...

The human amniotic membrane known as the innermost single epithelial-covered layer provides many applications such as applicable anti-inflammatory and anti-cancer effects. These immunomodulatory effects belongs to the epithelial cells, a type of epiblast-derived fetal stem cells which currently used for regenerative medicine and transplantation. These cells are collected by author-prepared faci...