The Caenorhabditis elegans synthetic multivulva (synMuv) genes act redundantly to antagonize the specification of vulval cell fates, which are promoted by an RTK/Ras pathway. At least 26 synMuv genes have been genetically identified, several of which encode proteins with homologs that act in chromatin remodeling or transcriptional repression. Here we report the molecular characterization of two...

lin-4 is essential for the normal temporal control of diverse postembryonic developmental events in C. elegans. lin-4 acts by negatively regulating the level of LIN-14 protein, creating a temporal decrease in LIN-14 protein starting in the first larval stage (L1). We have cloned the C. elegans lin-4 locus by chromosomal walking and transformation rescue. We used the C. elegans clone to isolate ...

Induction of vulval fates in the C. elegans hermaphrodite is mediated by a signal transduction pathway involving Ras and MAP kinase. Previous genetic analysis has suggested that two potential targets of this pathway in the vulva precursor cells are two novel proteins, LIN-25 and SUR-2. In this report, we describe further studies of lin-25. The results of a genetic mosaic analysis together with ...

1 1Institute of Earth Sciences, Academia Sinica, Nankang, Taipei, Taiwan, ROC 2Institute of Statistics, National Central University, Chungli, Taiwan, ROC 3Institute of Space Science, National Central University, Chungli, Taiwan, ROC 4Department of Geosciences, National Taiwan Normal University, Taipei, Taiwan, ROC *Corresponding author address: Prof. C. H. Lin, Institute of Earth Sciences, Acad...

Dr. Haifan Lin is professor of Cell Biology at Yale University, where he studies the mechanism of stem cell self-renewal in fruit flies, mice, and human cancer cells. Recently named director of the Yale Stem Cell Center, Dr. Lin has made seminal contributions to the stem cell field, most notably his demonstration of the stem cell niche theory using the fruit fly model, his discovery of the PIWI...

LIM homeobox family members regulate a variety of cell fate choices during animal development. In C. elegans, mutations in the LIM homeobox gene lin-11 have previously been shown to alter the cell division pattern of a subset of the 2 degrees lineage vulval cells. We demonstrate multiple functions of lin-11 during vulval development. We examined the fate of vulval cells in lin-11 mutant animals...

© 1997 DIGITALSTOCK Feature * This work was supported in parts by NSC 95-2221-E-009-080, NSC94-2752-E-002-006-PAE, and NSC 95-2221-E-002-197, Taiwan, R.O.C. FIRST QUARTER 2007 1531-636X/07/$25.00©2007 IEEE IEEE CIRCUITS AND SYSTEMS MAGAZINE 19 Authorized licensed use limited to: National Chiao Tung University. Downloaded on October 13, 2008 at 06:43 from IEEE Xplore. Restrictions apply. 20 IEEE...

This project will explore the application of graphbased algorithms to identifying predominant word senses. The hypothesis is that graph-based algorithms, by considering indirect relationships between words, will be more effective at identifying the predominant senses of words than approaches which only consider a word’s immediate context.

Using proteomic selection, functional verification, and clinical validation, we identified specific down-regulation of Lin-7C/VELI3/MALS-3 (Lin-7C), which marks oral squamous cell carcinoma (OSCC) metastasis. Despite a rarity of sequence variations in the Lin-7C gene in both primary OSCC and OSCC-derived cells, a high prevalence of hypermethylation was detected in the CpG island region that str...

Linarin (LIN), a flavonoid which exerts both anti-inflammatory and antioxidative effects, has been found to promote osteogenic differentiation. However, the molecular mechanism of its effect on osteoblast differentiation was unclear. In the present study, LIN from Flos Chrysanthemi Indici (FCI) was isolated in order to investigate the underlying mechanisms of LIN on MC3T3-E1 cells (a mouse oste...