Malignant peripheral nerve sheath tumors (MPNSTs) are rare, aggressive soft tissue sarcomas with a high rate of recurrence and metastasis. Limb salvage surgery free flap reconstruction is viable option for selected patients MPNSTs, but careful consideration should be given to the risk recurrence. This case report describes 26-year-old male patient recurrent, aggressive, high-grade MPNST who und...

Some replantation cases require substantial bone shortening for primary closure. Leg-length discrepancy can be restored by lengthening of the replanted or revascularized extremities. Between 1991 and 2000, four patients with four total and two subtotal below-knee amputations had replantation or revascularization for their severely damaged extremities. All of them had extensive debridement, vasc...

Background & Aims: Osteosarcoma is one of the most prevalent malignant bone tumors . This study is designed to assess the prognostic effect of pathologic fracture and treatment options on survival of patients with osteosarcoma. Materials & Methods: In this study, prognosis of 106 patients with limb osteosarcoma, which were treated at three  hospitals in Tehran from April to August 2012 ...

The treatment of lower limb tumors has been shifted by advancements in adjuvant treatment protocols and microsurgical reconstruction from limb amputation to limb salvage. Standard approaches include oncological surgery by a multidisciplinary team in terms of limb sparing followed by soft tissue reconstruction and adjuvant therapy when indicated. For the development of a comprehensive surgical p...