BACKGROUND Revascularization alternatives for patients with critical limb ischemia and without adequate autogenous vein remain challenging. We reviewed our experience with the use of arterial homograft as a conduit for limb salvage in patients with limb ischemia and active lower extremity infections. METHODS A retrospective review of patients who underwent open arterial revascularization of t...

Chronic limb-threatening ischemia (CLTI) is a common condition with high rates of morbidity and mortality, as well racial, ethnic, socioeconomic, geographic disparities; however, process measures for CLTI care have not been developed. We developed the Limb threatening Ischemia Process PERformance (CLIPPER) cohort to create test quality CLTI. Using inpatient outpatient claims data from patients ...

The first case of novel corona virus disease (COVID-19) was reported in China and undoubtedly today this has rapidly crossed borders, infecting people throughout the world. There are heaps complications related to COVID-19 namely acute respiratory failure, liver kidney injury, bacterial fungal infections, septic shock. Vascular thrombosis is another burden that pilling on load its complications...

Severe limb ischemia, due to advanced peripheral artery disease (PAD), is associated with a high risk of cardiovascular events and all-cause mortality and a poor prognosis with respect to limb preservation. In nonrevascularizable, so-called no-option patients with severe limb ischemia, 6-month major amputation rates have been reported to range from 10% to 40%. Severe limb ischemia is associated...

BACKGROUND/AIMS Ischemia induced by large-vessel obstruction or vascular injury induces a complex cascade of vasodilatory, remodeling and inflammatory pathways; coordination of these processes by vascular endothelium is likely to involve endothelial gap junctions. Vascular endothelium predominantly expresses two connexin (Cx) isoforms: Cx37 and Cx40. The relevance of these Cxs to postischemic l...

The aim of this paper is to investigate effect and mechanism of Danhong injection (DH) on angiogenesis in the diabetic hind limb ischemia mouse model. Thirty diabetic hind limb ischemic model mice and ten normal mice, established by intraperitoneal (i.p.) injection of streptozotocin (STZ) or PBS and ligation/excision of femoral artery, and then twenty diabetic hind limb ischemic model mice of a...

BACKGROUND AND PURPOSE Remote ischemic preconditioning is a phenomenon by which a short period of sublethal ischemia to an organ protects against subsequent ischemia in another organ. We have recently demonstrated that remote ischemic conditioning by transient hind limb ischemia delivered during ischemia and before reperfusion can provide potent cardioprotection, a phenomenon we termed per-cond...

OBJECTIVE Our aim was to assess the risk of major amputation or death after leg bypass surgery for critical limb ischemia in patients with diabetes versus those without. RESEARCH DESIGN AND METHODS We did a population-based cohort study by linking nationwide databases in Sweden. We identified 1,840 patients in the Swedish Vascular Registry who had their first leg bypass procedure for critical...

The protective mechanism underlying remote ischemic preconditioning (RIPC) is unclear. This study aims to verify whether the protein expression profile in the serum could be altered by RIPC and to detect potential protein mediators. Transient limb ischemia consisting of three cycles of 5-min ischemia followed by 5-min reperfusion was performed on sixty healthy volunteers. Serum samples were col...