نتایج جستجو برای: like tumors
تعداد نتایج: 820207 فیلتر نتایج به سال:
Abstract Histone 3 lysine27-to-methionine mutant diffuse midline gliomas (H3-K27M DMGs) are among the most lethal brain tumors. Their putative cellular hierarchy has been shown to be driven by self-renewing stem-like cells arrested in an oligodendrocyte precursor-like (OPC-like) state, of which few able differentiate towards more mature astrocyte (AC)-like and (OC)-like cells. However, spatial ...
In this work, highly infiltrative brain tumors with a stem-like phenotype were established by xenotransplantation of human brain tumors in immunodeficient nude rats. These tumors coopted the host vasculature and presented as an aggressive disease without signs of angiogenesis. The malignant cells expressed neural stem cell markers, showed a migratory behavior similar to normal human neural stem...
Background & Aim: Colorectal cancer is the third most common cancer and the third leading cause of cancer death. Most often it is derived from an adenomatous polyp. Therefore, detection and treatment of these baseline polyps could potentially decrease the prevalence and incidence of colorectal cancers. One of these screening procedures is colonoscopy, which is more Precise than others lik...
CONTEXT The cancer associated Sm-like proto-oncogene mRNA has been found to be overexpressed in the majority of pancreatic adenocarcinomas and is necessary for the transformed phenotype in pancreatic cancer cell lines. However, expression levels have not been examined in other types of pancreatic neoplasms, such as pancreatic endocrine tumors. SETTING Fifteen primary pancreatic endocrine tumo...
cancer stem cells (cscs) are unique subpopulations that have the capacity to drive malignant progression with renewal abilities. recently the role of some of cscs in gastric adenocarcinoma has been studied. this study was performed in order to evaluate cd44 and cd133 expressions by immunohistochemistry in 95 primary gastric adenocarcinoma and their relation to clinical and pathological paramete...
The diagnosis of cutaneous and subcutaneous spindle cell neoplasms in children is often challenging has potential therapeutic prognostic implications. Although correctly diagnosing dermatofibrosarcoma protuberans infantile fibrosarcoma paramount, pathologists should not ignore a number diagnostic pitfalls linked to mostly rare tumors with completely different clinical outcomes. In the last deca...
The majority of human breast cancers exhibit luminal epithelial differentiation. However, most aggressive behavior, including invasion and purported cancer stem cell activity, are considered characteristics of basal-like cells. We asked the following questions: Must luminal-like breast cancer cells become basal-like to initiate tumors or to invade? Could luminally differentiated cells within a ...
PURPOSE Expression profiling studies classified breast carcinomas into estrogen receptor (ER)+/luminal, normal breast-like, HER2 overexpressing, and basal-like groups, with the latter two associated with poor outcomes. Currently, there exist clinical assays that identify ER+/luminal and HER2-overexpressing tumors, and we sought to develop a clinical assay for breast basal-like tumors. EXPERIM...
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