نتایج جستجو برای: lifespan

تعداد نتایج: 15331  

Journal: :Journal of Epidemiology & Community Health 1992

Journal: :The Journal of experimental biology 2013
Kristjan Niitepõld Ilkka Hanski

High peak metabolic rates may provide a performance advantage, but it may also entail a physiological cost. A long-held assumption is that high mass-specific energy expenditure is associated with short lifespan. To examine the relationship between energy expenditure and lifespan we asked two questions. First, do individuals have a consistent rate of metabolism throughout their life? Second, is ...

2017
Justin Werfel Donald E. Ingber Yaneer Bar-Yam

Standard evolutionary theories of aging and mortality, implicitly based on assumptions of spatial averaging, hold that natural selection cannot favor shorter lifespan without direct compensating benefit to individual reproductive success. However, a number of empirical observations appear as exceptions to or are difficult to reconcile with this view, suggesting explicit lifespan control or prog...

2010
Eric L. Greer Travis J. Maures Anna G. Hauswirth Erin M. Green Dena S. Leeman Géraldine S. Maro Shuo Han Max R. Banko Or Gozani Anne Brunet

The plasticity of ageing suggests that longevity may be controlled epigenetically by specific alterations in chromatin state. The link between chromatin and ageing has mostly focused on histone deacetylation by the Sir2 family, but less is known about the role of other histone modifications in longevity. Histone methylation has a crucial role in development and in maintaining stem cell pluripot...

Journal: :Nucleic acids research 2000
M T Hemann C W Greider

Telomere length and telomerase activity directly affect the replicative capacity of primary human cells. Some have suggested that telomere length influences organismal lifespan. We compared telomere length distributions in a number of inbred and outbred established mouse strains with those of strains recently derived from wild mice. Telomere length was considerably shorter in wild-derived strai...

Journal: :PLoS Biology 2006
David Reznick Michael Bryant Donna Holmes

The study of post-reproductive lifespan has been of interest primarily with regard to the extended post-menopausal lifespan seen in humans. This unusual feature of human demography has been hypothesized to have evolved because of the "grandmother" effect, or the contributions that post-reproductive females make to the fitness of their children and grandchildren. While some correlative analyses ...

Journal: :Proceedings of the National Academy of Sciences of the United States of America 2004
Ted Brummel Alisa Ching Laurent Seroude Anne F Simon Seymour Benzer

We researched the lifespan of Drosophila under axenic conditions compared with customary procedure. The experiments revealed that the presence of bacteria during the first week of adult life can enhance lifespan, despite unchanged food intake. Later in life, the presence of bacteria can reduce lifespan. Certain long-lived mutants react in different ways, indicating an interplay between bacteria...

Journal: :Aging Cell 2009
Eric L Greer Anne Brunet

Dietary restriction (DR) has the remarkable ability to extend lifespan and healthspan. A variety of DR regimens have been described in species ranging from yeast to mammals. However, whether different DR regimens extend lifespan via universal, distinct, or overlapping pathways is still an open question. Here we examine the genetic pathways that mediate longevity by different DR regimens in Caen...

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